ArticleVeterinary research2013
Immune gene expression profiling of Proliferative Kidney Disease in rainbow trout Oncorhynchus mykiss reveals a dominance of anti-inflammatory, antibody and T helper cell-like activities.
Article in Veterinary research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- The Discovery ofAnimals : an open access journal from MDPI · 2026Article
- Tissue-Specific Transcriptomic Insights into Myxozoan Infections: Immune and Stress Responses in the Kidney and Head Cartilage of Rainbow Trout.International journal of molecular sciences · 2026Article
- Aquafeed Enrichment with Dictyota Dichotoma and Bacillus Coagulans: A Synergistic Strategy to Promote Growth, Immune Function, and Antioxidant Defensive Pathways in Cyprinus Carpio.Marine biotechnology (New York, N.Y.) · 2026Article
- Transcriptomic signatures differentiating carrier and dead-end fish hosts of proliferative kidney disease.Frontiers in cellular and infection microbiology · 2026Article
- Transcriptomic Analysis of the Rainbow Trout Response to Single and Co-Infections withInternational journal of molecular sciences · 2025Article
- Parental influence on brown trout offspring immune cell composition: An infection study with Tetracapsuloides bryosalmonae.PloS one · 2025Article
- The myxozoansFrontiers in cellular and infection microbiology · 2024Article
- The Immune Response to the Myxozoan ParasiteInternational journal of molecular sciences · 2023Review
- The efficacy of new oral vaccine feeds againstFish and shellfish immunology reports · 2023Article
- Tissue Reaction to Low-Density Polyacrylamide Gel as a Carrier for Microimplants in the Adipose Fin of Rainbow Trout.Gels (Basel, Switzerland) · 2023Article
- Responses to pathogen exposure in sentinel juvenile fall-run Chinook salmon in the Sacramento River, CA.Conservation physiology · 2023Article
- Red blood cells in proliferative kidney disease-rainbow trout (Frontiers in immunology · 2023Article
- Infection by the ParasiteMicroorganisms · 2022Article
- Genome-wide alternative splicing profile in the posterior kidney of brown trout (Salmo trutta) during proliferative kidney disease.BMC genomics · 2022Article
- Identification ofFrontiers in cellular and infection microbiology · 2022Article
- Kinetics of Parasite-Specific Antibody and B-Cell-Associated Gene Expression in Brown Trout,Biology · 2021Article
- It's a hard knock life for some: Heterogeneity in infection life history of salmonids influences parasite disease outcomes.The Journal of animal ecology · 2021Article
- Cranial Mandibular Fibrosis Syndrome in Adult Farmed Rainbow TroutPathogens (Basel, Switzerland) · 2021Article
- Review
- Evolutionary Analysis of Cystatins of Early-Emerging Metazoans Reveals a Novel Subtype in Parasitic Cnidarians.Biology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myxozoan Tetracapsuloides bryosalmonae is the causative agent of Proliferative Kidney Disease (PKD) targeting primarily the kidney of infected fish where it causes a chronic lymphoid immunopathology. Although known to be associated with suppression of some cellular aspects of innate immunity and a prominent lymphocytic hyperplasia, there remains a considerable knowledge gap in our understanding of the underlying immune mechanisms driving PKD pathogenesis. To provide further insights, the expression profiles of a panel of innate/inflammatory and adaptive immune molecules were examined in rainbow trout Oncorhynchus mykiss following a natural exposure to the parasite. Relative to controls, fish with early to advanced stages of kidney pathology exhibited up-regulation of the inflammatory cytokines interleukin (IL)-6 and IL-11, although remaining refractory towards genes indicative of macrophage activity. Antimicrobial peptides (AMPs) and anti-inflammatory markers, including cathelicidin (CATH) and IL-10 were markedly up-regulated during clinical disease. Up-regulation of adaptive immune molecules, including cell markers and antibody genes reflect the lymphocytic dominance of this disease and the likely importance of lymphocyte subsets in PKD pathogenesis. Up-regulation of T helper (TH) cell-like response genes and transcription factors implies that T. bryosalmonae may elicit a complex interplay between TH cell subsets. This work, for the first time in the study of fish-myxozoan interactions, suggests that PKD pathogenesis is shaped by an anti-inflammatory phenotype, a profound B cell/antibody response and dysregulated TH cell-like activities. A better understanding of the functional roles of fish immune cells and molecules in PKD pathogenesis may facilitate future development of control measures against this disease.
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