Trial reportBMC nephrology2013
Association of HbA1c and cardiovascular and renal disease in an adult Mediterranean population.
Trial report in BMC nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between glycated hemoglobin variability and risk of diabetic kidney disease and diabetic retinopathy in diabetic patients: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Pooled it
- Development and Validation of a Nomogram for Predicting Chronic Kidney Disease in Older Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease.Journal of multidisciplinary healthcare · 2026Article
- Supporting people with type 2 diabetes mellitus through the REDE D+ social prescribing program: feasibility of a non-randomized pilot study.Frontiers in public health · 2026Article
- New composite phenotypes enhance chronic kidney disease classification and genetic associations.PLoS genetics · 2025Article
- Challenges to hemoglobin A1c as a therapeutic target for type 2 diabetes mellitus.Journal of general and family medicine · 2019Review
- Interaction between gender and uric acid on hemoglobin A1c in community-dwelling persons.Journal of endocrinological investigation · 2018Article
- Elevated hemoglobin glycation index identify non-diabetic individuals at increased risk of kidney dysfunction.Oncotarget · 2017Article
- Glycated Hemoglobin is Independently Associated with Albuminuria in Young Nondiabetic People with Obesity: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- The Clinical Significance of HbA1c in Operable Chronic Thromboembolic Pulmonary Hypertension.PloS one · 2016Article
- HbA1c Levels Are Associated with Chronic Kidney Disease in a Non-Diabetic Adult Population: A Nationwide Survey (KNHANES 2011-2013).PloS one · 2015Article
- HbA1c for diagnosis of type 2 diabetes. Is there an optimal cut point to assess high risk of diabetes complications, and how well does the 6.5% cutoff perform?Diabetes, metabolic syndrome and obesity : targets and therapy · 2013Review
- Cardio-renal-metabolic (CRM): Call for action for European Guidelines for Primary Care Physicians.Journal of primary care & community healthReview
- Mildly elevated serum total bilirubin is negatively associated with hemoglobin A1c independently of confounding factors among community-dwelling middle-aged and elderly persons.Journal of circulating biomarkersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing evidence suggests a mechanistic link between the glycemic environment and renal and cardiovascular events, even below the threshold for diabetes. We aimed to assess the association between HbA1c and chronic kidney disease (CKD) and cardiovascular disease (CVD).
methodsA cross-sectional study involving a random representative sample of 2270 adults from southern Spain (Malaga) was undertaken. We measured HbA1c, serum creatinine and albuminuria in fasting blood and urine samples.
resultsIndividuals without diabetes in the upper HbA1c tertile had an unfavorable cardiovascular and renal profile and shared certain clinical characteristics with the patients with diabetes. Overall, a higher HbA1c concentration was strongly associated with CKD or CVD after adjustment for traditional risk factors. The patients with known diabetes had a 2-fold higher odds of CKD or CVD. However, when both parameters were introduced in the same model, the HbA1c concentration was only significantly associated with clinical endpoints (OR: 1.4, 95% CI, 1.1-1.6, P = 0.002). An increase in HbA1c of one percentage point was associated with a 30% to 40% increase in the rate of CKD or CVD. This relationship was apparent in persons with and without known diabetes. ROC curves illustrated that a HbA1c of 37 mmol/mol (5.5%) was the optimal value in terms of sensitivity and specificity for predicting endpoints in this population.
conclusionHbA1c levels were associated with a higher prevalence of CKD and CVD cross-sectionally, regardless of diabetes status. These data support the value of HbA1c as a marker of cardiovascular and renal disease in the general population.
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