ArticleBioMed research international2013
Remarkable anti-trichomonas vaginalis activity of plants traditionally used by the Mbyá-Guarani indigenous group in Brazil.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Induction of apoptosis by hydroalcoholic and methanolic extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Anti-parasitic activity of nanoJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Bioactive Compounds as Potential Agents for Sexually Transmitted Diseases Management: A Review to Explore Molecular Mechanisms of Action.Frontiers in pharmacology · 2021Review
- Therapeutic Potential of Brazilian CerradoMolecules (Basel, Switzerland) · 2018Review
- Are the fatty acids responsible for the higher effect of oil and alcoholic extract of Nigella sativa over its aqueous extract on Trichomonas vaginalis trophozoites?Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Natural and synthetic compound anti-Trichomonas vaginalis: an update review.Parasitology research · 2015Review
- In Vitro Activity ofIranian journal of parasitologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichomonas vaginalis, a flagellate protozoan, is the causative agent of trichomonosis, the most common nonviral sexually transmitted disease worldwide. Taking into account the increased prevalence of metronidazole-resistant isolates, alternative drugs are essential for the successful treatment. Natural products are the source of most new drugs, and popular wisdom about the use of medicinal plants is a powerful tool in this search. In this study, the activity of 10 medicinal plants extensively used in daily life by Mbyá-Guarani indigenous group was evaluated against seven different T. vaginalis isolates. Among the aqueous extracts tested, Verbena sp. (Guachu ka'a in Mbyá-Guarani language) and Campomanesia xanthocarpa (Guavira in Mbyá-Guarani language) showed the highest activity against T. vaginalis with MIC value of 4.0 mg/mL reaching 100% of efficacy against the parasite. The kinetic growth assays showed that the extracts promoted complete growth abolishment after 4 h of incubation. In addition, the extracts tested did not promote a significant hemolytic activity against human erythrocytes. Our results show for the first time the potential activity of Verbena sp. and C. xanthocarpa against T. vaginalis. In addition, this study demonstrates that indigenous knowledge is an important source of new prototype antiprotozoal agents.
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