ArticleJournal of amino acids2013
An Evaluation of Interindividual Responses to the Orally Administered Neurotransmitter β -Alanine.
Article in Journal of amino acids, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.Advances in nutrition (Bethesda, Md.) · 2019Pooled it
- Effects of Acute Beta-Alanine Ingestion and Immersion-Plus-Exercise on Connectedness to Nature and Perceived Pain.International journal of environmental research and public health · 2021Trial
- The Effect of β-Alanine Supplementation on Performance, Cognitive Function and Resiliency in Soldiers.Nutrients · 2023Review
- Increased Bioavailability of β-Alanine by a Novel Controlled-Release Powder Blend Compared to a Slow-Release Tablet.Pharmaceutics · 2021Article
- Sex differences and considerations for female specific nutritional strategies: a narrative review.Journal of the International Society of Sports Nutrition · 2021Review
- Bioprospecting of Palmyra Palm (Frontiers in microbiology · 2021Article
- The effects of 10 weeks of β-alanine supplementation on peak power, power drop, and lactate response in Korean national team boxers.Journal of exercise rehabilitation · 2018Article
- Proteomic profile of the Bradysia odoriphaga in response to the microbial secondary metabolite benzothiazole.Scientific reports · 2016Article
- β-Alanine supplementation and military performance.Amino acids · 2015Review
- International society of sports nutrition position stand: Beta-Alanine.Journal of the International Society of Sports Nutrition · 2015Review
- Perinatal hypoxia: different effects of the inhibitors of GABA transporters GAT1 and GAT3 on the initial velocity of [3H]GABA uptake by cortical, hippocampal, and thalamic nerve terminals.Croatian medical journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we have identified β -alanine as a potential endogenous anticonvulsant molecule. β -Alanine occurs within the human central nervous system and has been identified as both an inhibitory neuromodulator and neurotransmitter that is bioavailable to brain after oral administration. During preliminary compounding trials to ascertain dosing strategies for β -alanine, we noted pronounced differences in the side effect profile experienced by individuals of Asian and Caucasian descent. To investigate whether ethnicity affects β -alanine-induced side effects, we administered 3 g of β -alanine in 200 mL of fruit drink to ten people of each ethnic background and observed them for 30 minutes. Data collected included basic physical statistics (height, age, and weight) and descriptions of all side effects, as reported by participants. We found that participants of Asian descent experienced paraesthesia, but significantly different in time of onset, intensity, and anatomical localization, as compared to the effects experienced by Caucasian participants. Since β -alanine is an endogenous neurotransmitter substance within human brain, these side effect differences were unexpected.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.