ArticleMolecular biology of the cell2013
Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Unraveling the molecular details of centriole elongation.Trends open · 2026Article
- CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.Genes & development · 2026Article
- Review
- Loss of Cep135 causes oligoasthenoteratozoospermia and male infertility in mice.Cellular and molecular life sciences : CMLS · 2025Article
- Emerging roles of centrosome cohesion.Open biology · 2022Review
- Article
- Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.JCI insight · 2021Article
- Molecular Genetics of Microcephaly Primary Hereditary: An Overview.Brain sciences · 2021Review
- The sperm centrioles.Molecular and cellular endocrinology · 2020Review
- Article
- Separation and Loss of Centrioles From Primordidal Germ Cells To Mature Oocytes In The Mouse.Scientific reports · 2018Article
- Centrosome function and assembly in animal cells.Nature reviews. Molecular cell biology · 2015Review
- Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation.Nature communications · 2015Article
- The centrosome and its duplication cycle.Cold Spring Harbor perspectives in biology · 2015Review
- Cartwheel assembly.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis.Nature structural & molecular biology · 2014Article
- Molecular and cellular basis of autosomal recessive primary microcephaly.BioMed research international · 2014Review
- Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
Centrosomes are key microtubule-organizing centers that contain a pair of centrioles, conserved cylindrical, microtubule-based structures. Centrosome duplication occurs once per cell cycle and relies on templated centriole assembly. In many animal cells this process starts with the formation of a radially symmetrical cartwheel structure. The centrosomal protein Cep135 localizes to this cartwheel, but its role in vertebrates is not well understood. Here we examine the involvement of Cep135 in centriole function by disrupting the Cep135 gene in the DT40 chicken B-cell line. DT40 cells that lack Cep135 are viable and show no major defects in centrosome composition or function, although we note a small decrease in centriole numbers and a concomitant increase in the frequency of monopolar spindles. Furthermore, electron microscopy reveals an atypical structure in the lumen of Cep135-deficient centrioles. Centrosome amplification after hydroxyurea treatment increases significantly in Cep135-deficient cells, suggesting an inhibitory role for the protein in centrosome reduplication during S-phase delay. We propose that Cep135 is required for the structural integrity of centrioles in proliferating vertebrate cells, a role that also limits centrosome amplification in S-phase-arrested cells.
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