ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Cytoskeletal determinants of stimulus-response habits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 38 citations in OpenAlex.
- Cocaine and habit training cause dendritic spine rearrangement in the prelimbic cortex.iScience · 2023Article
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- Habit, choice, and addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Review
- Interfacing behavioral and neural circuit models for habit formation.Journal of neuroscience research · 2020Review
- Habitual Preference for the Nondrug Reward in a Drug Choice Setting.Frontiers in behavioral neuroscience · 2020Article
- The Fyn kinase inhibitor, AZD0530, suppresses mouse alcohol self-administration and seeking.Addiction biology · 2019Article
- Impulsivity and compulsivity are differentially associated with automaticity and routine on the Creature of Habit Scale.Personality and individual differences · 2019Article
- Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder.Psychopharmacology · 2019Article
- Inflexible habitual decision-making during choice between cocaine and a nondrug alternative.Translational psychiatry · 2019Article
- Defining the place of habit in substance use disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Memory Retention Involves the Ventrolateral Orbitofrontal Cortex: Comparison with the Basolateral Amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- A single cocaine exposure disrupts actin dynamics in the cortico-accumbal pathway of adolescent rats: modulation by a second cocaine injection.Psychopharmacology · 2017Article
- Connections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor.Biological psychiatry · 2017Article
- Adolescent cocaine self-administration induces habit behavior in adulthood: sex differences and structural consequences.Translational psychiatry · 2016Article
- Role of the Perigenual Anterior Cingulate and Orbitofrontal Cortex in Contingency Learning in the Marmoset.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Effects of the modern food environment on striatal function, cognition and regulation of ingestive behavior.Current opinion in behavioral sciences · 2016Article
- Strain commonalities and differences in response-outcome decision making in mice.Neurobiology of learning and memory · 2016Article
- Going and stopping: Dichotomies in behavioral control by the prefrontal cortex.Nature neuroscience · 2016Article
- The Medial Orbitofrontal Cortex Regulates Sensitivity to Outcome Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice.Psychopharmacology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Both humans and rodents can learn to associate specific actions with their outcomes, but with repeated performance or exposure to pathological stimuli, such as drugs of abuse, behaviors assume stimulus-elicited, or "habitual," qualities. Psychostimulants remodel dorsal striatal neurons, critical determinants of decision-making strategies, but cytoskeletal mechanisms associated with drug-induced habit formation are largely unknown. We first show that cocaine can bias decision-making strategies toward stimulus-response habits by interfering with learning about the predictive relationship between a response and its outcome. In the dorsomedial, but not ventral, striatum, cocaine decreases PSD95 expression and phosphorylation of cortactin, a cytoskeletal regulator that interacts with, and is phophorylated by, the Abl2 (Arg) kinase. Based on this pattern, we inhibited Abl-family kinase signaling in the dorsomedial striatum, impairing new response-outcome learning. Consistent with evidence that the dorsomedial striatum promotes response-outcome decision-making while the dorsolateral compartment promotes stimulus-response habits, inhibition of Abl-family kinases in the dorsolateral striatum reinstates goal sensitivity in over-trained "habitual" mice. These findings provide a structural mechanism by which even acute exposure to drugs of abuse can reorganize behavioral response strategies and promote outcome-insensitive stimulus-response habits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.