ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Efference copy failure during smooth pursuit eye movements in schizophrenia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder.Schizophrenia (Heidelberg, Germany) · 2025Article
- The neurofucntional abnormalities of temporal gyrus underly impaired sensory attenuation in schizophrenia during action-outcome contingent paradigm.Scientific reports · 2025Article
- Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.Brain communications · 2025Article
- A corollary discharge circuit in human speech.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Evidence for an Association Between a pH-Dependent Potassium Channel, TWIK-1, and the Accuracy of Smooth Pursuit Eye Movements.Investigative ophthalmology & visual science · 2024Article
- Aberrant sense of agency induced by delayed prediction signals in schizophrenia: a computational modeling study.Schizophrenia (Heidelberg, Germany) · 2023Article
- Atypical visual motion prediction abilities in autism spectrum disorder.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- Voluntary control of auditory hallucinations: phenomenology to therapeutic implications.NPJ schizophrenia · 2020Review
- Prediction, Psychosis, and the Cerebellum.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Disrupted Corollary Discharge in Schizophrenia: Evidence From the Oculomotor System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Review
- Schizophrenia and Corollary Discharge: A Neuroscientific Overview and Translational Implications.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Attenuated resting-state functional connectivity in patients with childhood- and adult-onset schizophrenia.Schizophrenia research · 2018Article
- Transsaccadic Perception Deficits in Schizophrenia Reflect the Improper Internal Monitoring of Eye Movement Rather Than Abnormal Sensory Processing.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Oculomotor Prediction: A Window into the Psychotic Mind.Trends in cognitive sciences · 2017Review
- Eye movements of patients with schizophrenia in a natural environment.European archives of psychiatry and clinical neuroscience · 2016Article
- Disrupted sensorimotor and social-cognitive networks underlie symptoms in childhood-onset schizophrenia.Brain : a journal of neurology · 2016Article
- Failure to use corollary discharge to remap visual target locations is associated with psychotic symptom severity in schizophrenia.Journal of neurophysiology · 2015Article
- Disrupted Saccadic Corollary Discharge in Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Processing of visually evoked innate fear by a non-canonical thalamic pathway.Nature communications · 2015Article
- Corollary Discharge Failure in an Oculomotor Task Is Related to Delusional Ideation in Healthy Individuals.PloS one · 2015Article
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5 authors.
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Abstract
Abnormal smooth pursuit eye movements in patients with schizophrenia are often considered a consequence of impaired motion perception. Here we used a novel motion prediction task to assess the effects of abnormal pursuit on perception in human patients. Schizophrenia patients (n = 15) and healthy controls (n = 16) judged whether a briefly presented moving target ("ball") would hit/miss a stationary vertical line segment ("goal"). To relate prediction performance and pursuit directly, we manipulated eye movements: in half of the trials, observers smoothly tracked the ball; in the other half, they fixated on the goal. Strict quality criteria ensured that pursuit was initiated and that fixation was maintained. Controls were significantly better in trajectory prediction during pursuit than during fixation, their performance increased with presentation duration, and their pursuit gain and perceptual judgments were correlated. Such perceptual benefits during pursuit may be due to the use of extraretinal motion information estimated from an efference copy signal. With an overall lower performance in pursuit and perception, patients showed no such pursuit advantage and no correlation between pursuit gain and perception. Although patients' pursuit showed normal improvement with longer duration, their prediction performance failed to benefit from duration increases. This dissociation indicates relatively intact early visual motion processing, but a failure to use efference copy information. Impaired efference function in the sensory system may represent a general deficit in schizophrenia and thus contribute to symptoms and functional outcome impairments associated with the disorder.
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