ArticleLearning & memory (Cold Spring Harbor, N.Y.)2013
Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdala.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- A neurally constrained computational model of context-dependent fear extinction recall and relapse.Communications biology · 2025Article
- Basal forebrain innervation of the amygdala: an anatomical and computational exploration.Brain structure & function · 2025Article
- Article
- Basolateral amygdala oscillations enable fear learning in a biophysical model.bioRxiv : the preprint server for biology · 2024Article
- Computational modeling of fear and stress responses: validation using consolidated fear and stress protocols.Frontiers in systems neuroscience · 2024Article
- Reverse engineering information processing in lateral amygdala during auditory tones.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2023Article
- Emotional Memory Processing during REM Sleep with Implications for Post-Traumatic Stress Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Agent-based modeling of the central amygdala and pain using cell-type specific physiological parameters.PLoS computational biology · 2021Article
- Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons.Cell reports · 2021Article
- Role of lateral amygdala calstabin2 in regulation of fear memory.Molecular brain · 2020Article
- Memory engrams: Recalling the past and imagining the future.Science (New York, N.Y.) · 2020Review
- The Interplay of Synaptic Plasticity and Scaling Enables Self-Organized Formation and Allocation of Multiple Memory Representations.Frontiers in neural circuits · 2020Article
- A Computational Model Integrating Multiple Phenomena on Cued Fear Conditioning, Extinction, and Reinstatement.Frontiers in systems neuroscience · 2020Article
- Embracing Complexity in Defensive Networks.Neuron · 2019Review
- A model of amygdala function following plastic changes at specific synapses during extinction.Neurobiology of stress · 2019Article
- Maintenance of postsynaptic neuronal excitability by a positive feedback loop of postsynaptic BDNF expression.Cognitive neurodynamics · 2018Article
- Article
- Distinct current modules shape cellular dynamics in model neurons.Neuroscience · 2016Article
- Uncertainty-Dependent Extinction of Fear Memory in an Amygdala-mPFC Neural Circuit Model.PLoS computational biology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The relative contributions of plasticity in the amygdala vs. its afferent pathways to conditioned fear remain controversial. Some believe that thalamic and cortical neurons transmitting information about the conditioned stimulus (CS) to the lateral amygdala (LA) serve a relay function. Others maintain that thalamic and/or cortical plasticity is critically involved in fear conditioning. To address this question, we developed a large-scale biophysical model of the LA that could reproduce earlier findings regarding the cellular correlates of fear conditioning in LA. We then conducted model experiments that examined whether fear memories depend on (1) training-induced increases in the responsiveness of thalamic and cortical neurons projecting to LA, (2) plasticity at the synapses they form in LA, and/or (3) plasticity at synapses between LA neurons. These tests revealed that training-induced increases in the responsiveness of afferent neurons are required for fear memory formation. However, once the memory has been formed, this factor is no longer required because the efficacy of the synapses that thalamic and cortical neurons form with LA cells has augmented enough to maintain the memory. In contrast, our model experiments suggest that plasticity at synapses between LA neurons plays a minor role in maintaining the fear memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.