ArticleJournal of virology2013
The HEX1 gene of Fusarium graminearum is required for fungal asexual reproduction and pathogenesis and for efficient viral RNA accumulation of Fusarium graminearum virus 1.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Identifying transcription factors associated with Fusarium graminearum virus 2 accumulation in Fusarium graminearum by phenome-based investigation.Virus research · 2023Article
- Two distinct Fusarium graminearum populations colonized European wheat in the past two decades.PloS one · 2023Article
- Strategies for Controlling the Sporulation inJournal of fungi (Basel, Switzerland) · 2022Review
- Metatranscriptomic Analysis Reveals Rich Mycoviral Diversity in Three Major Fungal Pathogens of Rice.International journal of molecular sciences · 2022Article
- Six Novel Mycoviruses Containing Positive Single-Stranded RNA and Double-Stranded RNA Genomes Co-Infect a Single Strain of theViruses · 2022Article
- NADPH Oxidase Gene,Frontiers in microbiology · 2022Review
- Twinfilin regulates actin assembly and Hexagonal peroxisome 1 (Hex1) localization in the pathogenesis of rice blast fungus Magnaporthe oryzae.Molecular plant pathology · 2021Article
- A second capsidless hadakavirus strain with 10 positive-sense single-stranded RNA genomic segments from Fusarium nygamai.Archives of virology · 2021Article
- Proteomics-Based Data Integration of Wheat Cultivars FacingFrontiers in plant science · 2021Article
- Hex1, the Major Component of Woronin Bodies, Is Required for Normal Development, Pathogenicity, and Stress Response in the Plant Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2020Article
- Dynamic Regulation of Peroxisomes and Mitochondria during Fungal Development.Journal of fungi (Basel, Switzerland) · 2020Review
- Establishment of Neurospora crassa as a model organism for fungal virology.Nature communications · 2020Article
- MrHex1 is Required for Woronin Body Formation, Fungal Development and Virulence inJournal of fungi (Basel, Switzerland) · 2020Article
- Molecular Characterization of a Novel Strain of Fusarium graminearum Virus 1 InfectingViruses · 2020Article
- The ORF2 protein of Fusarium graminearum virus 1 suppresses the transcription of FgDICER2 and FgAGO1 to limit host antiviral defences.Molecular plant pathology · 2020Article
- HexA is required for growth, aflatoxin biosynthesis and virulence in Aspergillus flavus.BMC molecular biology · 2019Article
- Mycoviruses inFrontiers in cellular and infection microbiology · 2019Review
- Expression of a Structural Protein of the Mycovirus FgV-ch9 Negatively Affects the Transcript Level of a Novel Symptom Alleviation Factor and Causes Virus Infection-Like Symptoms in Fusarium graminearum.Journal of virology · 2018Article
- Differential Contribution of RNA Interference Components in Response to Distinct Fusarium graminearum Virus Infections.Journal of virology · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accumulation of viral RNA depends on many host cellular factors. The hexagonal peroxisome (Hex1) protein is a fungal protein that is highly expressed when the DK21 strain of Fusarium graminearum virus 1 (FgV1) infects its host, and Hex1 affects the accumulation of FgV1 RNA. The Hex1 protein is the major constituent of the Woronin body (WB), which is a peroxisome-derived electron-dense core organelle that seals the septal pore in response to hyphal wounding. To clarify the role of Hex1 and the WB in the relationship between FgV1 and Fusarium graminearum, we generated targeted gene deletion and overexpression mutants. Although neither HEX1 gene deletion nor overexpression substantially affected vegetative growth, both changes reduced the production of asexual spores and reduced virulence on wheat spikelets in the absence of FgV1 infection. However, the vegetative growth of deletion and overexpression mutants was increased and decreased, respectively, upon FgV1 infection compared to that of an FgV1-infected wild-type isolate. Viral RNA accumulation was significantly decreased in deletion mutants but was significantly increased in overexpression mutants compared to the viral RNA accumulation in the virus-infected wild-type control. Overall, these data indicate that the HEX1 gene plays a direct role in the asexual reproduction and virulence of F. graminearum and facilitates viral RNA accumulation in the FgV1-infected host fungus.
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