ArticlePsychosomatic medicine2013
Disturbed sleep and inflammatory cytokines in depressed and nondepressed pregnant women: an exploratory analysis of pregnancy outcomes.
Article in Psychosomatic medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Association between maternal sleep duration and quality, and the risk of preterm birth: a systematic review and meta-analysis of observational studies.BMC pregnancy and childbirth · 2020Pooled it
- Insomnia and the risk of depression: a meta-analysis of prospective cohort studies.BMC psychiatry · 2016Pooled it
- Mediating role of sleep disorders in the association between depression and infertility: A cross-sectional study using the National Health and nutrition examination survey.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Maternal sleep deprivation and developmental programming of brain aging trajectories in offspring.Biogerontology · 2026Review
- The Role of IL-6 in the Diagnosis of Neonatal Sepsis and Its Influence on Maternal Mental Health.Cureus · 2025Article
- Association between sleep during pregnancy and birth outcomes: a prospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Comparison of longitudinal PSQI and actigraphy-assessed sleep from pregnancy to postpartum.PloS one · 2025Article
- Association of sleep duration in pregnancy with preterm birth in China: a cross-sectional survey.Frontiers in pediatrics · 2025Article
- Circadian rhythm regulates the function of immune cells and participates in the development of tumors.Cell death discovery · 2024Review
- Prenatal mood and anxiety disorders and associated cytokine changes.Journal of affective disorders · 2024Article
- Maternal exposure to zolpidem and risk of specific birth defects.Journal of sleep research · 2024Article
- Is There an Inflammatory Profile of Perinatal Depression?Current psychiatry reports · 2023Review
- Screening Depressive Symptoms and Incident Major Depressive Disorder Among Chinese Community Residents Using a Mobile App-Based Integrated Mental Health Care Model: Cohort Study.Journal of medical Internet research · 2022Article
- Effect of cognitive-behavioral training on fear of childbirth and sleep quality of pregnant adolescent slum dwellers.Journal of education and health promotion · 2022Article
- Association between perceived stress and depression among medical students during the outbreak of COVID-19: The mediating role of insomnia.Journal of affective disorders · 2021Review
- Association of maternal sleep before and during pregnancy with sleep and developmental problems in 1-year-old infants.Scientific reports · 2021Observational
- Sleep Disordered Breathing Measures in Early Pregnancy Are Associated with Depressive Symptoms in Late Pregnancy.Diagnostics (Basel, Switzerland) · 2021Article
- Daytime Napping and Nighttime Sleep During Pregnancy and Preterm Birth in Iran.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2021Article
- Maternal Sleep and Related Pregnancy Outcomes: A Multicenter Cross-Sectional Study in 11 Provinces of Iran.Journal of family & reproductive health · 2021Article
- Sleep Disturbance in Early Pregnancy, but Not Inflammatory Cytokines, May Increase Risk for Adverse Pregnancy Outcomes.International journal of behavioral medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveDisturbed sleep and depression are potential risk factors for pregnancy complications. Both conditions are known to dysregulate biological pathways responsible for maintaining homeostatic balance and pregnancy health. Depression during pregnancy is associated with poor sleep. Thus, we explored whether disturbed sleep was associated with inflammatory cytokines and risk for adverse pregnancy outcomes, as well as whether depression augmented the sleep-cytokine relationship, thereby additively contributing to risk for adverse outcomes.
methodsInterview-assessed sleep and plasma cytokine concentrations were evaluated in a cohort of depressed and nondepressed pregnant women (n = 168) at 20 and 30 weeks' gestation. Outcomes evaluated included preterm birth, birth weight, and peripartum events.
resultsAmong depressed women, short sleep duration (<7 hours) was associated with higher interleukin (IL)-8 across time (β = 0.506, p = .001), poor sleep efficiency (<85%) was associated with higher IL-6 (β = 0.205, p = .006), and daytime naps were associated with higher tumor necrosis factor α (β = 0.105, p = .024). Aspects of poor sleep were associated with having a lower weight baby (p values <.053). Among depressed women, interferon-γ increased risk for preterm birth (odds ratio = 1.175, p = .032). Trends for IL-6 and higher birth weight (β = 105.2, p = .085), interferon-γ and lower birth weight (β = -19.92, p < .069), and increased IL-8 and babies weighing less than 4000 grams (odds ratio = 0.72, p < .083) were observed.
conclusionsAlthough speculative, disturbed sleep may disrupt normal immune processes and contribute to adverse pregnancy outcomes. Exploratory analyses indicate that depression modifies these relationships.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.