ArticleJournal of the Royal Society, Interface2013
Applicability of ToF-SIMS for monitoring compositional changes in bone in a long-term animal model.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Nanoscopic imaging of ancient protein and vasculature offers insight into soft tissue and biomolecule fossilization.iScience · 2024Article
- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
- Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Rats.Bioengineering (Basel, Switzerland) · 2023Article
- ToF-SIMS Analysis of Demineralized Dentin Biomodified with Calcium Phosphate and Collagen Crosslinking: Effect on Marginal Adaptation of Class V Adhesive Restorations.Materials (Basel, Switzerland) · 2021Article
- Podosome-Driven Defect Development in Lamellar Bone under the Conditions of Senile Osteoporosis Observed at the Nanometer Scale.ACS biomaterials science & engineering · 2021Article
- Gelatin-Modified Calcium/Strontium Hydrogen Phosphates Stimulate Bone Regeneration in Osteoblast/Osteoclast Co-Culture and in Osteoporotic Rat Femur Defects-In Vitro to In Vivo Translation.Molecules (Basel, Switzerland) · 2020Article
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- Analysis of microscopic bone properties in an osteoporotic sheep model: a combined biomechanics, FE and ToF-SIMS study.Journal of the Royal Society, Interface · 2019Article
- Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometry.Journal of the Royal Society, Interface · 2019Article
- Effects of a Pasty Bone Cement Containing Brain-Derived Neurotrophic Factor-Functionalized Mesoporous Bioactive Glass Particles on Metaphyseal Healing in a New Murine Osteoporotic Fracture Model.International journal of molecular sciences · 2018Article
- Postembedding Decalcification of Mineralized Tissue Sections Preserves the Integrity of Implanted Biomaterials and Minimizes Number of Experimental Animals.BioMed research international · 2017Article
- Mass spectrometry imaging: a novel technology in rheumatology.Nature reviews. Rheumatology · 2017Review
- Spectroscopic Studies on Organic Matter from Triassic Reptile Bones, Upper Silesia, Poland.PloS one · 2016Article
- Impaired extracellular matrix structure resulting from malnutrition in ovariectomized mature rats.Histochemistry and cell biology · 2015Article
- Fibres and cellular structures preserved in 75-million-year-old dinosaur specimens.Nature communications · 2015Article
- Time of flight secondary ion mass spectrometry of bone-Impact of sample preparation and measurement conditions.Biointerphases · 2015Article
- Revealing cytokine-induced changes in the extracellular matrix with secondary ion mass spectrometry.Acta biomaterialia · 2015Article
- Small changes in bone structure of female α7 nicotinic acetylcholine receptor knockout mice.BMC musculoskeletal disorders · 2015Article
- Changes in the degree of mineralization with osteoporosis and its treatment.Current osteoporosis reports · 2014Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a well-established technique in material sciences but has not yet been widely explored for implementation in life sciences. Here, we demonstrate the applicability and advantages of ToF-SIMS analysis for the study of minerals and biomolecules in osseous tissue. The locally resolved analysis of fragment ions deriving from the sample surface enables imaging and differentiation of bone tissue and facilitates histology on non-stained cross sections. In a rat model, bilateral ovariectomy combined with either a multi-deficiency diet or steroid treatment was carried out to create osteoporotic conditions. We focused our study on the Ca content of the mineralized tissue and monitored its decline. Calcium mass images of cross sections show the progressive degenerative changes in the bone. We observed a decreased Ca concentration in the edge region of the trabeculae and a decline in the Ca/P ratio. Additionally, we focused on the non-mineralized matrix and identified fragment ions that are characteristic for the collagen matrix. We observed trabeculae with wide ranges of non-mineralized collagen for the diet group owing to an impaired mineralization process. Here, the advantage of coeval monitoring of collagen and minerals indicated an osteomalacic model rather than an osteoporotic one.
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