ArticleJournal of neurophysiology2013
Multichannel brain recordings in behaving Drosophila reveal oscillatory activity and local coherence in response to sensory stimulation and circuit activation.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster.Translational psychiatry · 2026Article
- Insight into molecular and neural mechanisms of general anesthesia from the invertebrate modelZoological research · 2025Review
- Wakefulness can be distinguished from general anesthesia and sleep in flies using a massive library of univariate time series analyses.PLoS biology · 2025Article
- Long-term multichannel recordings in Drosophila flies reveal altered predictive processing during sleep compared with wake.The Journal of experimental biology · 2025Article
- Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies.Science advances · 2024Article
- Multivariate classification of multichannel long-term electrophysiology data identifies different sleep stages in fruit flies.bioRxiv : the preprint server for biology · 2023Article
- Myogenic contraction of a somatic muscle powers rhythmic flow of hemolymph through Drosophila antennae and generates brain pulsations.The Journal of experimental biology · 2021Article
- Fly seizure EEG: field potential activity in theJournal of neurogenetics · 2021Article
- Integrated information structure collapses with anesthetic loss of conscious arousal in Drosophila melanogaster.PLoS computational biology · 2021Article
- The Slowest Shared Resonance: A Review of Electromagnetic Field Oscillations Between Central and Peripheral Nervous Systems.Frontiers in human neuroscience · 2021Review
- Oscillations in the central brain ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Beyond spikes: Multiscale computational analysis ofNetwork neuroscience (Cambridge, Mass.) · 2019Article
- The Effect of Common Signals on Power, Coherence and Granger Causality: Theoretical Review, Simulations, and Empirical Analysis of Fruit Fly LFPs Data.Frontiers in systems neuroscience · 2018Article
- Oscillatory brain activity in spontaneous and induced sleep stages in flies.Nature communications · 2017Article
- Closed-Loop Behavioral Control Increases Coherence in the Fly Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A framework for the first-person internal sensation of visual perception in mammals and a comparable circuitry for olfactory perception in Drosophila.SpringerPlus · 2015Article
- Abnormal visual gain control in a Parkinson's disease model.Human molecular genetics · 2014Article
- Optogenetic control of serotonin and dopamine release in Drosophila larvae.ACS chemical neuroscience · 2014Article
- Selective attention in the honeybee optic lobes precedes behavioral choices.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Neural networks in vertebrates exhibit endogenous oscillations that have been associated with functions ranging from sensory processing to locomotion. It remains unclear whether oscillations may play a similar role in the insect brain. We describe a novel "whole brain" readout for Drosophila melanogaster using a simple multichannel recording preparation to study electrical activity across the brain of flies exposed to different sensory stimuli. We recorded local field potential (LFP) activity from >2,000 registered recording sites across the fly brain in >200 wild-type and transgenic animals to uncover specific LFP frequency bands that correlate with: 1) brain region; 2) sensory modality (olfactory, visual, or mechanosensory); and 3) activity in specific neural circuits. We found endogenous and stimulus-specific oscillations throughout the fly brain. Central (higher-order) brain regions exhibited sensory modality-specific increases in power within narrow frequency bands. Conversely, in sensory brain regions such as the optic or antennal lobes, LFP coherence, rather than power, best defined sensory responses across modalities. By transiently activating specific circuits via expression of TrpA1, we found that several circuits in the fly brain modulate LFP power and coherence across brain regions and frequency domains. However, activation of a neuromodulatory octopaminergic circuit specifically increased neuronal coherence in the optic lobes during visual stimulation while decreasing coherence in central brain regions. Our multichannel recording and brain registration approach provides an effective way to track activity simultaneously across the fly brain in vivo, allowing investigation of functional roles for oscillations in processing sensory stimuli and modulating behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.