ArticleEuropean journal of epidemiology2013
Association between serum uric acid and the metabolic syndrome among a middle- and old-age Chinese population.
Article in European journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.BMJ (Clinical research ed.) · 2017Pooled it
- Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study.PLoS genetics · 2016Pooled it
- Serum uric acid levels are associated with polymorphisms in the SLC2A9, SF1, and GCKR genes in a Chinese population.Acta pharmacologica Sinica · 2014Pooled it
- The Association Between Serum Uric Acid Levels and the 10-Year Prospective Risk of Dyslipidemia: A Cohort Study From Healthy Heart Project (YHHP).Health science reports · 2025Article
- Article
- Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- The role of body mass index on the association between the energy-adjusted dietary inflammatory index and hyperuricemia: a mediation analysis based on NHANES (2007-2016).International journal of obesity (2005) · 2024Article
- Ruminal microbiota and muscle metabolome characteristics of Tibetan plateau yaks fed different dietary protein levels.Frontiers in microbiology · 2024Article
- Mendelian Randomization: A Powerful Tool to Illuminate Pathophysiologic Mechanisms.Mayo Clinic proceedings · 2023Article
- Association between hyperuricemia and hypertension and the mediatory role of obesity: a large cohort study in China.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Association between the Weight-Adjusted Waist Index and Serum Uric Acid: A Cross-Sectional Study.International journal of clinical practice · 2023Article
- Prevalence and Risk Factors of Comorbid Obesity in Chinese Patients with Bipolar Disorder.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Impaired sensitivity to thyroid hormones is associated with hyperuricemia in a Chinese euthyroid population.Frontiers in endocrinology · 2023Article
- Temporal changes in serum uric acid and risk for metabolic syndrome: a longitudinal cohort study.Diabetology & metabolic syndrome · 2022Article
- Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care.Nature reviews. Rheumatology · 2022Review
- Comparative analysis of anthropometric indices with serum uric acid in Iranian healthy population.Journal of clinical laboratory analysis · 2022Article
- The Association Between Total Percent Fat and Serum Uric Acid in Adults.Frontiers in nutrition · 2022Article
- No Evidence for a Causal Link between Serum Uric Acid and Nonalcoholic Fatty Liver Disease from the Dongfeng-Tongji Cohort Study.Oxidative medicine and cellular longevity · 2022Article
- Prevalence of hyperuricemia in patients with severe obesity and the relationship between serum uric acid and severe obesity: A decade retrospective cross-section study in Chinese adults.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our aim was to study whether there is causal association between serum uric acid and metabolic syndrome (MetS). A cross-sectional study was performed, including a total of 27,009 subjects (23,345 subjects having uric acid data) from the Dongfeng-Tongji Cohort study. The MetS was defined by the International Diabetes Foundation criteria of 2005. Association analysis was performed by logistic regression. A genetic risk score was calculated by adding the uric acid increasing alleles in two SNPs (rs11722228 in SLC2A9 and rs2231142 in ABCG2) which were identified from our genome-wide association study on uric acid levels. The causal association was examined by mendelian randomization analysis. Among a middle- and old-age Chinese population, serum uric acid concentrations were strongly associated with the risk of MetS and its several components (P < 0.0001). The effects were stronger in women than in men. Despite the lack of statistical significance, both SNPs exhibited a trend with increased MetS risk (rs11722228, OR = 1.06, 95 % CI 0.99-1.14; rs2231142, OR = 1.02, 95 % CI 0.95-1.10), consistent with their increasing uric acid effects. Each additional uric acid increasing allele in the genetic risk score was associated with 3 % increased MetS risk (OR = 1.03, 95 % CI 0.98-1.09; P = 0.23). Further adjustment for serum uric acid attenuated the trend of individual SNP and genetic risk score with increased MetS risk (all OR < 1.0). These findings suggested that serum uric acid was associated with MetS risk in a middle- and old-age Chinese population. Whether this association was causal remained to be investigated in the future studies.
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