ArticleNature communications2013
Femtolitre chemistry assisted by microfluidic pen lithography.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Advancements in Inkjet Printing of Metal- and Covalent-Organic Frameworks: Process Design and Ink Optimization.ACS applied materials & interfaces · 2025Review
- Data-Driven Materials Research and Development for Functional Coatings.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Copper-Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial and Angiogenic Properties.ACS omega · 2024Article
- Microfluidic High-Throughput Platforms for Discovery of Novel Materials.Nanomaterials (Basel, Switzerland) · 2020Review
- Article
- Chemistry in nanoconfined water.Chemical science · 2017Article
- The Diamond Light Source.Science progress · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical reactions at ultrasmall volumes are becoming increasingly necessary to study biological processes, to synthesize homogenous nanostructures and to perform high-throughput assays and combinatorial screening. Here we show that a femtolitre reaction can be realized on a surface by handling and mixing femtolitre volumes of reagents using a microfluidic stylus. This method, named microfluidic pen lithography, allows mixing reagents in isolated femtolitre droplets that can be used as reactors to conduct independent reactions and crystallization processes. This strategy overcomes the high-throughput limitations of vesicles and micelles and obviates the usually costly step of fabricating microdevices and wells. We anticipate that this process enables performing distinct reactions (acid-base, enzymatic recognition and metal-organic framework synthesis), creating multiplexed nanoscale metal-organic framework arrays, and screening combinatorial reactions to evaluate the crystallization of novel peptide-based materials.
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Registered trials
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