ArticleGenes and immunity2013
Identification of a KIR antisense lncRNA expressed by progenitor cells.
Article in Genes and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Identification of elements determiningiScience · 2026Article
- The role of long non-coding RNAs in NK cell biology and diseases.Genes & diseases · 2026Review
- Multi-omics analysis identifies TLRscore for prognostic prediction and highlights TLR8 in macrophage-mediated antitumor immunity of lung adenocarcinoma.Frontiers in immunology · 2026Article
- Article
- Dysregulation of lncRNAs in NK cells from breast cancer patients: implications for NK cell functions.Immunogenetics · 2025Article
- Review
- The KIR2DL1 intermediate upstream element participates in gene activation.Immunogenetics · 2023Article
- The HumanFrontiers in cell and developmental biology · 2019Article
- Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis.Non-coding RNA · 2018Review
- Article
- Long non-coding RNA: Functional agent for disease traits.RNA biology · 2017Review
- lncRNA-mediated regulation of the interferon response.Virus research · 2016Review
- Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity.International journal of molecular sciences · 2015Review
- The Emerging Functions of Long Noncoding RNA in Immune Cells: Autoimmune Diseases.Journal of immunology research · 2015Review
- Long Intergenic Non-Coding RNAs: Novel Drivers of Human Lymphocyte Differentiation.Frontiers in immunology · 2015Review
- Probabilistic bidirectional promoter switches: noncoding RNA takes control.Molecular therapy. Nucleic acids · 2014Article
- The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT).Immunological reviews · 2014Review
- Long noncoding RNAs in innate and adaptive immunity.Current opinion in immunology · 2014Review
- Small and Long Regulatory RNAs in the Immune System and Immune Diseases.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Human NK cells express cell surface class I MHC receptors (killer cell immunoglobulin-like receptor, KIR) in a probabilistic manner. Previous studies have shown that a distal promoter acts in conjunction with a proximal bidirectional promoter to control the selective activation of KIR genes. We report here the presence of an intron 2 promoter in several KIR genes that produce a spliced antisense transcript. This long noncoding RNA (lncRNA) transcript contains antisense sequence complementary to KIR-coding exons 1 and 2 as well as the proximal promoter region of the KIR genes. The antisense promoter contains myeloid zinc finger 1 (MZF-1)-binding sites, a transcription factor found in hematopoietic progenitors and myeloid precursors. The KIR antisense lncRNA was detected only in progenitor cells or pluripotent cell lines, suggesting a function that is specific for stem cells. Overexpression of MZF-1 in developing NK cells led to decreased KIR expression, consistent with a role for the KIR antisense lncRNA in silencing KIR gene expression early in development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.