ArticleScientific reports2013
Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial.Scientific reports · 2016Trial
- Determinants of fractal motor activity regulation: insights from a large community-dwelling multi-ethnic population.Research square · 2026Article
- Exercise and neural circuit stability in early Alzheimer's disease: evidence across memory, executive, cholinergic, and circadian systems.Frontiers in aging neuroscience · 2026Review
- Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Postural sway variability in young adults presents higher complexity during morning compared to evening hours while in older adults remains the same.Experimental brain research · 2025Article
- Fractal biomarker of daily activity for women with early onset depression.BMJ mental health · 2025Article
- Detecting the fractal physical activity pattern in aged adults with cerebral small vessel disease.Frontiers in aging neuroscience · 2025Article
- Reliable measures of rest-activity rhythm fragmentation: how many days are needed?European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure.Circulation research · 2024Review
- Altered Motor Activity Patterns within 10-Minute Timescale Predict Incident Clinical Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Fractals in Neuropsychology and Cognitive Neuroscience.Advances in neurobiology · 2024Article
- Impact of sleep disruption on cognitive function in patients with postacute sequelae of SARS-CoV-2 infection: initial findings from a Neuro-COVID-19 clinic.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Approaches for assessing circadian rest-activity patterns using actigraphy in cohort and population-based studies.Current sleep medicine reports · 2023Article
- Fractal complexity of daily physical activity and cognitive function in a midlife cohort.Scientific reports · 2023Article
- Measures of fragmentation of rest activity patterns: mathematical properties and interpretability based on accelerometer real life data.Research square · 2023Article
- Stride-to-Stride Fluctuations of Human Gait Are Affected By Chronobiology: An Exploratory Study.Advanced biology · 2023Article
- Personalized relapse prediction in patients with major depressive disorder using digital biomarkers.Scientific reports · 2023Article
- Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.Annals of neurology · 2023Article
- Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Circadian rhythms in neurodegenerative disorders.Nature reviews. Neurology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Human motor activity has a robust, intrinsic fractal structure with similar patterns from minutes to hours. The fractal activity patterns appear to be physiologically important because the patterns persist under different environmental conditions but are significantly altered/reduced with aging and Alzheimer's disease (AD). Here, we report that dementia patients, known to have disrupted circadian rhythmicity, also have disrupted fractal activity patterns and that the disruption is more pronounced in patients with more amyloid plaques (a marker of AD severity). Moreover, the degree of fractal activity disruption is strongly associated with vasopressinergic and neurotensinergic neurons (two major circadian neurotransmitters) in postmortem suprachiasmatic nucleus (SCN), and can better predict changes of the two neurotransmitters than traditional circadian measures. These findings suggest that the SCN impacts human activity regulation at multiple time scales and that disrupted fractal activity may serve as a non-invasive biomarker of SCN neurodegeneration in dementia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.