ArticleJournal of immunology (Baltimore, Md. : 1950)2013
ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Messing with Signal 1: How Perturbed MHC Class I Antigen Presentation Contributes to Cancer.Cells · 2026Review
- Loss of Tapasin in Tumors Potentiates T-Cell Recognition and Anti-Tumor Effects of Immune Checkpoint Blockade.Cancer science · 2025Article
- Antigen Presentation in the Lung.Frontiers in immunology · 2022Review
- Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.Frontiers in immunology · 2021Review
- ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.The Journal of biological chemistry · 2019Article
- Article
- Partial Dissociation of Truncated Peptides Influences the Structural Dynamics of the MHCI Binding Groove.Frontiers in immunology · 2017Article
- Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy.Molecular & cellular proteomics : MCP · 2016Article
- ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.Scientific reports · 2016Article
- Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Molecular mechanism of peptide editing in the tapasin-MHC I complex.Scientific reports · 2016Article
- Observational
- TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst.eLife · 2015Article
- The first step of peptide selection in antigen presentation by MHC class I molecules.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Distinct assembly profiles of HLA-B molecules.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.Current opinion in immunology · 2014Review
- Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition.OncoimmunologyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Effective CD8(+) T cell responses depend on presentation of a stable peptide repertoire by MHC class I (MHC I) molecules on the cell surface. The overall quality of peptide-MHC I complexes (pMHC I) is determined by poorly understood mechanisms that generate and load peptides with appropriate consensus motifs onto MHC I. In this article, we show that both tapasin (Tpn), a key component of the peptide loading complex, and the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP) are quintessential editors of distinct structural features of the peptide repertoire. We carried out reciprocal immunization of wild-type mice with cells from Tpn- or ERAAP-deficient mice. Specificity analysis of T cell responses showed that absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Changes in amino acid sequences of MHC-bound peptides revealed that ERAAP and Tpn, respectively, defined the characteristic amino and carboxy termini of canonical MHC I peptides. Thus, the optimal pMHC I repertoire is produced by two distinct peptide editing steps in the endoplasmic reticulum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.