ArticlePediatric research2013
Kinetics of procalcitonin and C-reactive protein and the relationship to postoperative infection in young infants undergoing cardiovascular surgery.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Evaluation of the Course of Acute-Phase Reactants in the Postoperative Period of Newborns and Their Diagnostic Utility in Identifying Postoperative Sepsis.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Infection…what else? The usefulness of procalcitonin in children after cardiac surgery.PloS one · 2021Observational
- Article
- The Dynamical Assessment of Inflammatory Biomarkers in Predicting the Outcome of Septic Patients and the Response to Antimicrobial Therapy.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2020Article
- Procalcitonin Concentration Measured Within the First Days of Cardiac Surgery Is Predictive of Postoperative Infections in Neonates: A Case-Control Study.Pediatric cardiology · 2019Article
- Procalcitonin as an Early Laboratory Marker of Sepsis in Neonates: Variation in Diagnostic Performance and Discrimination Value.The Malaysian journal of medical sciences : MJMS · 2019Article
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit-The PROSACAB study.PloS one · 2019Article
- Prognostic value of biomarkers after cardiopulmonary bypass in pediatrics: The prospective PANCAP study.PloS one · 2019Observational
- Is Procalcitonin Useful in Pediatric Critical Care Patients?Biomarker insights · 2018Review
- Kinetics of Procalcitonin in Pediatric Patients on Extracorporeal Membrane Oxygenation.Biomarker insights · 2018Review
- Procalcitonin Is a Better Biomarker than C-Reactive Protein in Newborns Undergoing Cardiac Surgery: The PROKINECA Study.Biomarker insights · 2016Article
- Elimination Half-Lives of Acute Phase Proteins in Rats and Beagle Dogs During Acute Inflammation.Inflammation · 2015Article
- C-Reactive protein kinetics after cardiac surgery: A retrospective multicenter study.Annals of cardiac anaesthesiaArticle
- Procalcitonin as a biomarker of bacterial infection in pediatric patients after congenital heart surgery.Annals of pediatric cardiologyArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe utility of procalcitonin (PCT) and C-reactive protein (CRP) as infectious biomarkers following infant cardiothoracic surgery is not well defined.
methodsWe designed a prospective cohort study to evaluate PCT and CRP after infant cardiothoracic surgery. PCT and CRP were drawn preoperatively and 24/72 h postoperation or daily in delayed sternal closure patients. Presence of infection within 10 d of surgery, vasoactive-inotropic scores at 24 and 72 h, and length of intubation, intensive care unit stay, and hospital stay were documented.
resultsPCT and CRP were elevated at 24 h. PCT then decreased while CRP increased in patients undergoing delayed sternal closure or cardiopulmonary bypass. In the delayed sternal closure group, PCT was significantly higher on postoperative days 2-5 in patients who ultimately developed infection. Higher PCT was independently associated with increased vasoactive-inotropic score at 72 h. CRP did not correlate with infection or postoperative support.
conclusionPCT rises after cardiothoracic surgery in infants but decreases by 72 h while CRP remains elevated. Sternal closure may affect CRP but not PCT. PCT is independently associated with circulatory support requirements at 72 h postoperation and with development of infection. PCT may have greater utility as a biomarker in this population.
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