ArticlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2013
Differences in medical therapy goals for children with severe traumatic brain injury-an international study.
Article in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Comparison of equiosmolar dose of hyperosmolar agents in reducing intracranial pressure-a randomized control study in pediatric traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Trial
- Inflammatory-neurodegenerative crosstalk in pediatric severe traumatic brain injury: a multi-domain plasma proteomic study.Molecular medicine (Cambridge, Mass.) · 2026Article
- Severe Traumatic Brain Injury in French-Speaking Pediatric Intensive Care Units: Study of Practices.Journal of pediatric intensive care · 2024Article
- Predicting inpatient mortality in pediatric traumatic brain injury: insights from a national database.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Incidence of acute neurosurgery for traumatic brain injury in children-a nationwide analysis from 1998 to 2018.Acta neurochirurgica · 2023Article
- Comparative Effectiveness of Diversion of Cerebrospinal Fluid for Children With Severe Traumatic Brain Injury.JAMA network open · 2022Observational
- Management of Severe Traumatic Brain Injury in Pediatric Patients.Frontiers in toxicology · 2022Review
- Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision.Journal of neurotrauma · 2020Review
- Evidence Limitations in Determining Sexually Dimorphic Outcomes in Pediatric Post-Traumatic Hypopituitarism and the Path Forward.Frontiers in neurology · 2020Review
- Monitoring and Measurement of Intracranial Pressure in Pediatric Head Trauma.Frontiers in neurology · 2019Review
- Challenges and opportunities for pediatric severe TBI-review of the evidence and exploring a way forward.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Targeted treatment in severe traumatic brain injury in the age of precision medicine.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
- K channel impairment determines sex and age differences in epinephrine-mediated outcomes after brain injury.Journal of neuroscience research · 2017Article
- Curcumin attenuates hypoxic-ischemic brain injury in neonatal rats through induction of nuclear factor erythroid-2-related factor 2 and heme oxygenase-1.Experimental and therapeutic medicine · 2017Article
- Tripartite Stratification of the Glasgow Coma Scale in Children with Severe Traumatic Brain Injury and Mortality: An Analysis from a Multi-Center Comparative Effectiveness Study.Journal of neurotrauma · 2017Article
- Sex and age differences in phenylephrine mechanisms and outcomes after piglet brain injury.Pediatric research · 2017Article
- Sex and Age Differences in Epinephrine Mechanisms and Outcomes after Brain Injury.Journal of neurotrauma · 2017Article
- International Survey of Critically Ill Children With Acute Neurologic Insults: The Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Observational
- Anatomical and Physiological Differences between Children and Adults Relevant to Traumatic Brain Injury and the Implications for Clinical Assessment and Care.Frontiers in neurology · 2017Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesTo describe the differences in goals for their usual practice for various medical therapies from a number of international centers for children with severe traumatic brain injury.
designA survey of the goals from representatives of the international centers.
settingThirty-two pediatric traumatic brain injury centers in the United States, United Kingdom, France, and Spain. PATIENTS: None.
interventionsNone. MEASUREMENTS AND MAIN
resultsA survey instrument was developed that required free-form responses from the centers regarding their usual practice goals for topics of intracranial hypertension therapies, hypoxia/ischemia prevention and detection, and metabolic support. Cerebrospinal fluid diversion strategies varied both across centers and within centers, with roughly equal proportion of centers adopting a strategy of continuous cerebrospinal fluid diversion and a strategy of no cerebrospinal fluid diversion. Use of mannitol and hypertonic saline for hyperosmolar therapies was widespread among centers (90.1% and 96.9%, respectively). Of centers using hypertonic saline, 3% saline preparations were the most common but many other concentrations were in common use. Routine hyperventilation was not reported as a standard goal and 31.3% of centers currently use PbO(2) monitoring for cerebral hypoxia. The time to start nutritional support and glucose administration varied widely, with nutritional support beginning before 96 hours and glucose administration being started earlier in most centers.
conclusionsThere were marked differences in medical goals for children with severe traumatic brain injury across our international consortium, and these differences seemed to be greatest in areas with the weakest evidence in the literature. Future studies that determine the superiority of the various medical therapies outlined within our survey would be a significant advance for the pediatric neurotrauma field and may lead to new standards of care and improved study designs for clinical trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.