Evidence map›Paper›PMID 23863764›Full record

ArticleNeurosurgery2013

Phosphodiesterase 4D single-nucleotide polymorphism 83 and cognitive dysfunction in carotid endarterectomy patients.

Eric J Heyer, Joanna L Mergeche, Justin T Ward, Hani R Malone, Christopher Kellner, Samuel S Bruce, E Sander Connolly

Expression of concern Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. It is linked to trial NCT00597883 (Neurologic and Neuropsychometric Outcome in Patients Undergoing Carotid Endarterectomy), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00597883 completednot on this map

Neurologic and Neuropsychometric Outcome in Patients Undergoing Carotid Endarterectomy

TypeobservationalSponsorColumbia UniversityRan2003 to 2014Enrolled817ConditionsCarotid Artery Stenosis, Carotid Artery Disease, Transient Ischemic Attack, StrokeArmsCarotid endarterectomy, Neurological and neuropsychological evaluations
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Eric J Heyer*Department of Anesthesiology, Columbia University, New York, New York; ‡Department of Neurology, Columbia University, New York, New York; §Department of Neurological Surgery, Columbia University, New York, New York.
Joanna L Mergeche
Justin T Ward
Hani R Malone
Christopher Kellner
Samuel S Bruce
E Sander Connolly
Columbia University · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Neuropsychological Outcome of Carotid EndarterectomyR01AG017604 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HEYER, ERIC JOHN · 2001 to 2012
$3.2M
NCATS NIH HHS UL1 TR000040NCRR NIH HHS UL1 RR024156NIA NIH HHS R01 AG017604NIA NIH HHS R01 AG17604
6 · The paper itself

Abstract

backgroundPhosphodiesterase 4D (PDE4D), through the regulation of cyclic AMP, modulates inflammation and other processes that affect atherosclerosis and stroke. A PDE4D polymorphism, single-nucleotide polymorphism (SNP) 83 (rs966221), is associated with ischemic stroke. The association of SNP 83 with postoperative cognitive dysfunction has never been investigated.

objectiveTo determine whether SNP 83 is associated with cognitive dysfunction 1 day and 1 month following carotid endarterectomy (CEA).

methodsThree hundred fourteen patients with high-grade carotid stenosis scheduled for CEA consented to participate in this single-center cohort study of cognitive dysfunction.

resultsPatients with the C/C genotype of SNP 83 exhibited significantly more cognitive dysfunction at 1 day (29.7%) than the C/T (15.8%, P = .008) and T/T (12.7%, P = .01) genotypes. In a multivariate logistic regression model, C/T and T/T genotypes were both associated with significantly decreased odds of cognitive dysfunction compared with the C/C genotype (odds ratio, 0.45 [0.24-0.83], P = .01 and odds ratio, 0.33 [0.12-0.77], P = .02). There were no significant associations at 1 month.

conclusionThe C/C genotype of SNP 83 is significantly associated with the highest incidence of cognitive dysfunction 1 day following CEA in comparison with the C/T and T/T genotypes. This PDE4D genotype may lead to accelerated cyclic AMP degradation and subsequently elevated inflammation 1 day after CEA. These observations, in conjunction with previous studies, suggest that elevated inflammatory states may be partially responsible for the development of cognitive dysfunction after CEA, but more investigation is required.

Indexed as

Endarterectomy, CarotidAgedAged, 80 and overCarotid StenosisCognition DisordersCohort StudiesCyclic Nucleotide Phosphodiesterases, Type 4FemaleGenotypeHumansMaleNeuropsychological TestsPolymorphism, Single NucleotidePostoperative ComplicationsRegression AnalysisStatistics, NonparametricCyclic Nucleotide Phosphodiesterases, Type 4

Identifiers

PMID23863764
PMCPMC3935380
OpenAlexW1982758096

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.