ArticleThe Journal of clinical investigation2013
Transcription factor EGR1 directs tendon differentiation and promotes tendon repair.
Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 2 of them syntheses that pooled it.
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Who cites it
136 citing papers in PubMed, 2 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Efficacy of stem cell therapy for achilles tendon rupture: a systematic review and meta-analysis based on animal studies.Frontiers in bioengineering and biotechnology · 2026Pooled it
- Understanding Tendons: Lessons from Transgenic Mouse Models.Stem cells and development · 2018Pooled it
- Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review).International journal of molecular medicine · 2026Review
- Effects of Mechanical Loading on the Structure and Function of the Achilles Tendon: From Homeostatic Adaptation to Pathological Degeneration.Journal of functional morphology and kinesiology · 2026Review
- Effect of human myoblasts on tenogenic progression in 2D and 3D culture models.Journal of anatomy · 2026Article
- Genetic Anatomy and Ontogenetic Roles of Early Growth Response 1 (Egr1) in Human and Mouse.Development & reproduction · 2026Review
- Article
- Stem cell approaches for tendon repair: delusion or insight.The Journal of physiology · 2025Review
- Hypoxia-Induced Metabolic Reprogramming and Markings of Cell Fate in Concentric Arterial Hypertrophy.bioRxiv : the preprint server for biology · 2025Article
- Human adipose stromal cells differentiate towards a tendon phenotype with adapted visco-elastic properties in a 3D-culture system.Biology open · 2025Article
- Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model.iScience · 2025Article
- Erroneous Differentiation of Tendon Stem/Progenitor Cells in the Pathogenesis of Tendinopathy: Current Evidence and Future Perspectives.Stem cell reviews and reports · 2025Review
- Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells.Stem cells international · 2025Article
- The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats.Frontiers in cell and developmental biology · 2025Article
- Modulation of EGR1 Expression by Hyperglycemia in Swine Rotator Cuff Tendons.Journal of orthopaedics and sports medicine · 2025Article
- A conserved transcription factor regulatory program promotes tendon fate.Developmental cell · 2024Article
- Effects of Late-Passage Small Umbilical Cord-Derived Fast Proliferating Cells on Tenocytes from Degenerative Rotator Cuff Tears under an Interleukin 1β-Induced Tendinopathic Environment.Tissue engineering and regenerative medicine · 2024Article
- The effects of zinc sulfate mineral supplementation on Achilles tendon healing in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- The histone H3K9 methyltransferase G9a regulates tendon formation during development.Scientific reports · 2024Article
- Limb connective tissue is organized in a continuum of promiscuous fibroblast identities during development.iScience · 2024Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Tendon formation and repair rely on specific combinations of transcription factors, growth factors, and mechanical parameters that regulate the production and spatial organization of type I collagen. Here, we investigated the function of the zinc finger transcription factor EGR1 in tendon formation, healing, and repair using rodent animal models and mesenchymal stem cells (MSCs). Adult tendons of Egr1-/- mice displayed a deficiency in the expression of tendon genes, including Scx, Col1a1, and Col1a2, and were mechanically weaker compared with their WT littermates. EGR1 was recruited to the Col1a1 and Col2a1 promoters in postnatal mouse tendons in vivo. Egr1 was required for the normal gene response following tendon injury in a mouse model of Achilles tendon healing. Forced Egr1 expression programmed MSCs toward the tendon lineage and promoted the formation of in vitro-engineered tendons from MSCs. The application of EGR1-producing MSCs increased the formation of tendon-like tissues in a rat model of Achilles tendon injury. We provide evidence that the ability of EGR1 to promote tendon differentiation is partially mediated by TGF-β2. This study demonstrates EGR1 involvement in adult tendon formation, healing, and repair and identifies Egr1 as a putative target in tendon repair strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.