ArticleThe Journal of clinical investigation2013
Chronic THC intake modifies fundamental cerebellar functions.
Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03662737 (A Visuomotor Rotation Task as a Biomarker of Cerebellar Dysfunction in Chronic Cannabis Use), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Visuomotor Rotation Task as a Biomarker of Cerebellar Dysfunction in Chronic Cannabis Use
Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of prenatal synthetic cannabinoid exposure on the cerebellum of adolescent rat offspring.Heliyon · 2021Article
- Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment.JAMA psychiatry · 2020Observational
- Genome-wide association study implicates CHRNA2 in cannabis use disorder.Nature neuroscience · 2019Article
- Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood.Developmental cognitive neuroscience · 2015Article
- Neuropsychological performance in adolescent marijuana users with co-occurring alcohol use: A three-year longitudinal study.Neuropsychology · 2015Article
- Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence.Journal of studies on alcohol and drugs · 2014Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Delta9-tetrahydrocannabinol (THC), the principal bioactive component in the Cannabis plant, is truly a captivating drug. Acute and chronic THC intake produces a spectrum of biological effects ranging from transient psychotropic effects to prolonged medicinal benefits, many of which have been fostered for centuries by our society. In the July 2013 issue of the JCI, Cutando et al. combined mouse genetics with classic mouse behavioral analysis to deepen our understanding of the physiological consequence of subchronic THC intake on eyeblink reflexes, a fundamental neuronal adaptive response, revealing that this regimen leads to downregulation of the cannabinoid CB1 receptor (referred to as CB1 in the Cutando et al. article) in cerebellar stress fibers and the activation of microglia, raising provocative new questions about the safety profile of regimented THC intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.