ArticleVirulence2013
Alcohol impairs J774.16 macrophage-like cell antimicrobial functions in Acinetobacter baumannii infection.
Article in Virulence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Community-acquiredFrontiers in medicine · 2026Article
- Case Report: Severe Community-Acquired Pneumonia in Réunion Island due to Acinetobacter baumannii.The American journal of tropical medicine and hygiene · 2024Article
- Article
- Carbapenemases: TransformingBiomolecules · 2020Review
- Insights intoAntibiotics (Basel, Switzerland) · 2020Review
- A TractableFrontiers in cellular and infection microbiology · 2020Article
- Potential Mechanisms of Mucin-Enhanced Acinetobacter baumannii Virulence in the Mouse Model of Intraperitoneal Infection.Infection and immunity · 2019Article
- Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset BacteremicOpen forum infectious diseases · 2019Article
- Acute intraperitoneal infection with a hypervirulent Acinetobacter baumannii isolate in mice.Scientific reports · 2019Article
- Genomic epidemiology of severe community-onset Acinetobacter baumannii infection.Microbial genomics · 2019Article
- Intracellular Invasion and Killing Assay to Investigate the Effectsof Binge Alcohol Toxicity in Murine Alveolar Macrophages.Bio-protocol · 2019Article
- Severe Community-Acquired Pneumonia due toOpen forum infectious diseases · 2018Article
- Uncovering the mechanisms of Acinetobacter baumannii virulence.Nature reviews. Microbiology · 2018Review
- An unusual cause of community-acquired pneumonia.IDCases · 2018Article
- Capsular specific IgM enhances complement-mediated phagocytosis and killing of Cryptococcus neoformans by methamphetamine-treated J774.16 macrophage-like cells.International immunopharmacology · 2017Article
- Malondialdehyde-Acetaldehyde-Adducted Surfactant Protein Alters Macrophage Functions Through Scavenger Receptor A.Alcoholism, clinical and experimental research · 2016Article
- Chronic Ethanol Exposure: Pathogenesis of Pulmonary Disease and Dysfunction.Biomolecules · 2015Review
- Article
- Community-acquired pneumonia infections by Acinetobacter baumannii: how does alcohol impact the antimicrobial functions of macrophages?Virulence · 2013Article
Corrections and comments
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4 authors at 3 institutions in 4 countries.
Funding
Abstract
Acinetobacter baumannii (Ab) is a common cause of community-acquired pneumonia (CAP) in chronic alcoholics in tropical and sub-tropical climates and associated with a > 50% mortality rate. We demonstrated that exposure of J774.16 macrophage-like cells to physiological alcohol (EtOH) concentrations decreased phagocytosis and killing of Ab. EtOH-mediated macrophage phagocytosis dysfunction may be associated with reduced expression of GTPase-RhoA, a key regulator of the actin polymerization signaling cascade. EtOH inhibited nitric oxide (NO) generation via inducible NO-synthase inactivation, which enhanced Ab survival within macrophages. Additionally, EtOH alters cytokine production resulting in a dysregulated immune response. This study is a proof of principle which establishes that EtOH might exacerbate Ab infection and be an important factor enhancing CAP in individuals at risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.