ArticleJournal of clinical microbiology2013
Description of an unusual Neisseria meningitidis isolate containing and expressing Neisseria gonorrhoeae-Specific 16S rRNA gene sequences.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Rapid and robust diagnosis of bloodstream infections by single-cell analysis.Science advances · 2026Article
- Global distribution of Xpert CT/NG assayEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025Article
- Evaluation of Biofilm Inhibitory Activity of Probiotics and Postbiotics Using In Vitro Biofilm Model of Canine Periodontal Disease.Microorganisms · 2025Article
- Diagnostic-avoiding Chlamydia trachomatis variants detected in cervical and endometrial specimens from women during 16S microbiome profiling.BMC infectious diseases · 2025Article
- Meningococcal Urethritis: Old and New.Journal of clinical microbiology · 2022Review
- Whole Genome Analyses Accurately IdentifyInternational journal of molecular sciences · 2022Article
- The Epidemiology of Meningococcal Disease and Carriage, Genotypic Characteristics and Antibiotic Resistance ofFrontiers in microbiology · 2021Article
- A polymicrobial biofilm model for testing the antimicrobial potential of a nisin-biogel for canine periodontal disease control.BMC veterinary research · 2020Article
- Division of the genusInternational journal of systematic and evolutionary microbiology · 2020Article
- Oropharyngeal microbiome of a college population following a meningococcal disease outbreak.Scientific reports · 2020Article
- Genotyping of commensal Neisseria spp strains by pulsed-field gel electrophoresis and 16S rRNA gene sequencing.Journal of clinical laboratory analysis · 2018Article
- Emergence of a newProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Targeted and highly multiplexed detection of microorganisms by employing an ensemble of molecular probes.Applied and environmental microbiology · 2014Article
- Identifying Neisseria species by use of the 50S ribosomal protein L6 (rplF) gene.Journal of clinical microbiology · 2014Article
- Benchmarking of methods for genomic taxonomy.Journal of clinical microbiology · 2014Article
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Authors and funding
5 authors.
Funding
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Abstract
An apparently rare Neisseria meningitidis isolate containing one copy of a Neisseria gonorrhoeae 16S rRNA gene is described herein. This isolate was identified as N. meningitidis by biochemical identification methods but generated a positive signal with Gen-Probe Aptima assays for the detection of Neisseria gonorrhoeae. Direct 16S rRNA gene sequencing of the purified isolate revealed mixed bases in signature regions that allow for discrimination between N. meningitidis and N. gonorrhoeae. The mixed bases were resolved by sequencing individually PCR-amplified single copies of the genomic 16S rRNA gene. A total of 121 discrete sequences were obtained; 92 (76%) were N. meningitidis sequences, and 29 (24%) were N. gonorrhoeae sequences. Based on the ratio of species-specific sequences, the N. meningitidis strain seems to have replaced one of its four intrinsic 16S rRNA genes with the gonococcal gene. Fluorescence in situ hybridization (FISH) probes specific for meningococcal and gonococcal rRNA were used to demonstrate the expression of the rRNA genes. Interestingly, the clinical isolate described here expresses both N. meningitidis and N. gonorrhoeae 16S rRNA genes, as shown by positive FISH signals with both probes. This explains why the probes for N. gonorrhoeae in the Gen-Probe Aptima assays cross-react with this N. meningitidis isolate. The N. meningitidis isolate described must have obtained N. gonorrhoeae-specific DNA through interspecies recombination.
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