ArticleDevelopment (Cambridge, England)2013
Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification.
Article in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Meta-analysis of Caenorhabditis elegans single-cell developmental data reveals multi-frequency oscillation in gene activation.Bioinformatics (Oxford, England) · 2020Pooled it
- Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors.The EMBO journal · 2025Article
- Coupling and decoupling of the cell cycle from cell differentiation in development.Development (Cambridge, England) · 2025Review
- Cell state transitions are decoupled from cell division during early embryo development.Nature cell biology · 2024Article
- Article
- Transcript accumulation rates in the earlyScience advances · 2023Article
- The GATA factor ELT-3 specifies endoderm in Caenorhabditis angaria in an ancestral gene network.Development (Cambridge, England) · 2022Article
- Physically asymmetric division of theeLife · 2021Article
- mRNA quantification using single-molecule FISH in Drosophila embryos.Nature protocols · 2017Article
- Timing of Tissue-specific Cell Division Requires a Differential Onset of Zygotic Transcription during Metazoan Embryogenesis.The Journal of biological chemistry · 2016Article
- Combinatorial decoding of the invariant C. elegans embryonic lineage in space and time.Genesis (New York, N.Y. : 2000) · 2016Review
- Mutagenesis of GATA motifs controlling the endoderm regulator elt-2 reveals distinct dominant and secondary cis-regulatory elements.Developmental biology · 2016Article
- The function and regulation of the GATA factor ELT-2 in the C. elegans endoderm.Development (Cambridge, England) · 2016Article
- Article
- MED GATA factors promote robust development of the C. elegans endoderm.Developmental biology · 2015Article
- Systems-level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry.Molecular systems biology · 2015Article
- Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms.Molecular cell · 2015Article
- Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing.G3 (Bethesda, Md.) · 2015Article
- Using variability in gene expression as a tool for studying gene regulation.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cell differentiation and proliferation are coordinated during animal development, but the link between them remains uncharacterized. To examine this relationship, we combined single-molecule RNA imaging with time-lapse microscopy to generate high-resolution measurements of transcriptional dynamics in Caenorhabditis elegans embryogenesis. We found that globally slowing the overall development rate of the embryo by altering temperature or by mutation resulted in cell proliferation and transcription slowing, but maintaining, their relative timings, suggesting that cell division may directly control transcription. However, using mutants with specific defects in cell cycle pathways that lead to abnormal lineages, we found that the order between cell divisions and expression onset can switch, showing that expression of developmental regulators is not strictly dependent on cell division. Delaying cell divisions resulted in only slight changes in absolute expression time, suggesting that expression and proliferation are independently entrained to a separate clock-like process. These changes in relative timing can change the number of cells expressing a gene at a given time, suggesting that timing may help determine which cells adopt particular transcriptional patterns. Our results place limits on the types of mechanisms that are used during normal development to ensure that division timing and fate specification occur at appropriate times.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.