ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
The effect of aging on acetaminophen pharmacokinetics, toxicity and Nrf2 in Fischer 344 rats.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Elderly mice with history of acetaminophen intoxication display worsened cognitive impairment and persistent elevation of astrocyte and microglia burden.Scientific reports · 2024Article
- A cutting-edge new framework for the pain management in children: nanotechnology.Frontiers in molecular neuroscience · 2024Review
- Article
- Weaning Mice and Adult Mice Exhibit Differential Carbon Tetrachloride-Induced Acute Hepatotoxicity.Antioxidants (Basel, Switzerland) · 2020Article
- Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats.PeerJ · 2019Article
- Immature mice are more susceptible than adult mice to acetaminophen-induced acute liver injury.Scientific reports · 2017Article
- N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice.Fundamental & clinical pharmacology · 2016Article
- Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.Fundamental & clinical pharmacology · 2016Article
- Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type.Experimental gerontology · 2016Article
- The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats.Experimental gerontology · 2015Article
- Pharmacokinetics study of asperosaponin VI and its metabolites cauloside A, HN saponin F and hederagenin.Journal of natural medicines · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
We investigated the effect of aging on hepatic pharmacokinetics and the degree of hepatotoxicity following a toxic dose of acetaminophen. Young and old male Fischer 344 rats were treated with 800 mg/kg acetaminophen (young n = 8, old n = 5) or saline (young n = 9, old n = 9). Serum measurements showed old rats treated with acetaminophen had significantly lower serum alanine aminotransferase and higher acetaminophen and acetaminophen glucuronide levels and creatinine, compared with acetaminophen treated young rats (p < .05). Immunoblotting and activity assays showed old saline-treated rats had twofold lower cytochrome P450 2E1 activity and threefold higher NAD(P)H quinone oxireductase 1 protein expression and activity than young saline-treated rats (p < .05), although Nrf2, glutathione cysteine ligase-modulatory subunit, glutathione cysteine ligase-catalytic subunit, and cytochrome P450 2E1 protein expressions were unchanged. Primary hepatocytes isolated from young rats treated with 10 mM acetaminophen had lower survival than those from old rats (52.4% ± 5.8%, young; 83.6% ± 1.7%, old, p < .05). The pharmacokinetic changes described may decrease susceptibility to acetaminophen-induced hepatotoxicity but may increase risk of nephrotoxicity in old age.
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Registered trials
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