ArticleThe journal of physical chemistry. B2013
Quantitative characterization of the compensating effects of trimethylamine-N-oxide and guanidine hydrochloride on the dissociation of human cyanmethmoglobin.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Simultaneous quantification of trimethylamine N-oxide, trimethylamine, choline, betaine, creatinine, and propionyl-, acetyl-, and L-carnitine in clinical and food samples using HILIC-LC-MS.Analytical and bioanalytical chemistry · 2021Article
- Recent applications of light scattering measurement in the biological and biopharmaceutical sciences.Analytical biochemistry · 2016Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Dynamic light scattering was used to measure the extent of dissociation of human cyanmethemoglobin (HbCN) α2β2 tetramers into αβ dimers as a function of HbCN concentration in the presence of varying concentrations of guanidine hydrochloride (GuHCl) and trimethylamine-N-oxide (TMAO). It was found that increasing concentrations of GuHCl enhance the dissociation of HbCN, and that GuHCl-induced dissociation is progressively inhibited with increasing concentrations of TMAO. The effects of both cosolutes upon the free energy of HbCN dissociation are shown to be additive. The effect of TMAO on Hb dissociation is largely attributed to steric volume exclusion but is partially compensated by a small attractive interaction between TMAO and the protein.
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Registered trials
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