ArticleBiology open2013
transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival.
Article in Biology open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 107 citations in OpenAlex.
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- Modeling the effects of genetic- and diet-induced obesity on melanoma progression in zebrafish.Disease models & mechanisms · 2023Article
- A Drosophila model of the neurological symptoms in Mpv17-related diseases.Scientific reports · 2022Article
- A Yeast-Based Repurposing Approach for the Treatment of Mitochondrial DNA Depletion Syndromes Led to the Identification of Molecules Able to Modulate the dNTP Pool.International journal of molecular sciences · 2021Article
- Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish.Genome biology · 2021Article
- Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish.Cell death discovery · 2021Article
- Genetics of white color and iridophoroma in "Lemon Frost" leopard geckos.PLoS genetics · 2021Article
- The Zebrafish Cardiac Endothelial Cell-Roles in Development and Regeneration.Journal of cardiovascular development and disease · 2021Review
- A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots.PLoS genetics · 2021Article
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- Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line.Frontiers in cellular neuroscience · 2021Article
- Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish.Nature communications · 2020Article
- Mimicry Embedding Facilitates Advanced Neural Network Training for Image-Based Pathogen Detection.mSphere · 2020Article
- Insights into the Evolution of Neoteny from the Genome of the Asian Icefish Protosalanx chinensis.iScience · 2020Article
- The zebrafish as a novel model for theDisease models & mechanisms · 2020Article
- Physiology and molecular biology of plants : an international journal of functional plant biology · 2020Article
- Genome and Transcriptome Sequencing ofInternational journal of molecular sciences · 2020Article
Corrections and comments
- Erratum issuedErratum:2013 · Astrinides, Pantilis [corrected to Astrinidis, Pantelis]
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the skin of adult zebrafish, three pigment cell types arrange into alternating horizontal stripes, melanophores in dark stripes, xanthophores in light interstripes and iridophores in both stripes and interstripes. The analysis of mutants and regeneration studies revealed that this pattern depends on interactions between melanophores and xanthophores; however, the role of iridophores in this process is less understood. We describe the adult viable and fertile mutant transparent (tra), which shows a loss or strong reduction of iridophores throughout larval and adult stages. In addition, in adults only the number of melanophores is strongly reduced, and stripes break up into spots. Stripes in the fins are normal. By cell transplantations we show that tra acts cell-autonomously in iridophores, whereas the reduction in melanophores in the body occurs secondarily as a consequence of iridophore loss. We conclude that differentiated iridophores are required for the accumulation and maintenance of melanophores during pigment pattern formation. The tra mutant phenotype is caused by a small deletion in mpv17, an ubiquituously expressed gene whose protein product, like its mammalian and yeast homologs, localizes to mitochondria. Iridophore death might be the result of mitochondrial dysfunction, consistent with the mitochondrial DNA depletion syndrome observed in mammalian mpv17 mutants. The specificity of the tra phenotype is most likely due to redundancy after gene multiplication, making this mutant a valuable model to understand the molecular function of Mpv17 in mitochondria.
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