ArticlePloS one2013
Fate mapping for activation-induced cytidine deaminase (AID) marks non-lymphoid cells during mouse development.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Activation-induced deaminase expression defines mature B cell lymphoma in the mouse.Frontiers in immunology · 2023Article
- Single cell clonal analysis identifies an AID-dependent pathway of plasma cell differentiation.EMBO reports · 2022Article
- Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI response.NPJ precision oncology · 2022Article
- Article
- The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers.The Journal of experimental medicine · 2021Article
- B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.Cell reports · 2020Article
- Human MYD88L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells.Blood advances · 2019Article
- B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging.The Journal of experimental medicine · 2019Article
- BCR affinity differentially regulates colonization of the subepithelial dome and infiltration into germinal centers within Peyer's patches.Nature immunology · 2019Article
- PTEN-Regulated AID Transcription in Germinal Center B Cells Is Essential for the Class-Switch Recombination and IgG Antibody Responses.Frontiers in immunology · 2018Article
- Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.Oncogene · 2016Article
- Involvement of activation-induced cytidine deaminase in skin cancer development.The Journal of clinical investigation · 2016Article
- Deletion of Rb1 induces both hyperproliferation and cell death in murine germinal center B cells.Experimental hematology · 2016Article
- Epigenetic Codes Programing Class Switch Recombination.Frontiers in immunology · 2015Review
- AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The Aicda gene encodes Activation-Induced cytidine Deaminase (AID), an enzyme essential for remodeling antibody genes in mature B lymphocytes. AID is also responsible for DNA damage at oncogenes, leading to their mutation and cancer-associated chromosome translocation in lymphoma. We used fate mapping and AID(GFP) reporter mice to determine if AID expression in the mouse extends beyond lymphocytes. We discovered that AID(cre) tags a small fraction of non-lymphoid cells starting at 10.5 days post conception (dpc), and that AID(GFP+) cells are detectable at dpc 11.5 and 12.5. Embryonic cells are tagged by AID(cre) in the submandibular region, where conditional deletion of the tumor suppressor PTEN causes squamous papillomas. AID(cre) also tags non-lymphoid cells in the embryonic central nervous system. Finally, in the adult mouse brain, AID(cre) marks a small fraction of diverse neurons and distinct neuronal populations, including pyramidal cells in cortical layer IV.
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Registered trials
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