ArticlePloS one2013
Iron status and Helicobacter pylori infection in symptomatic children: an international multi-centered study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 83 citations in OpenAlex.
- Infection byHaematologica · 2024Article
- Review
- A nationwide cohort study suggests clarithromycin-based therapy for Helicobacter pylori eradication is safe in patients with stable coronary heart disease and subsequent peptic ulcer disease.BMC gastroenterology · 2022Article
- Review
- Is Helicobacter Pylori a Reason for Unexplained Iron Deficiency Anemia: A Systematic Review.Cureus · 2022Review
- Low isolated ferritin levels without anemia: is gastrointestinal tract endoscopy sufficient to explain the cause?Irish journal of medical science · 2022Article
- Article
- AsymptomaticNutrients · 2019Article
- Helicobacter pylori infection in children: an overview of diagnostic methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Helicobacter pylori among symptomatic Egyptian children: prevalence, risk factors, and effect on growth.The Journal of the Egyptian Public Health Association · 2019Article
- Effect of Helicobacter pylori Treatment on Unexplained Iron Deficiency Anemia.The Permanente journal · 2019Article
- Shifts in the Human Gut Microbiota Structure Caused by QuadrupleFrontiers in microbiology · 2019Article
- Epidemiological and Clinical-Pathological Aspects ofGastroenterology research and practice · 2018Article
- Relationship between β-Thalassemia minor andCaspian journal of internal medicine · 2018Article
- Current Status of the Third-LineGastroenterology research and practice · 2018Review
- Metabolic Interaction of Helicobacter pylori Infection and Gut Microbiota.Microorganisms · 2016Review
- Current views of the relationship between Helicobacter pylori and Henoch-Schonlein purpura in children.World journal of clinical pediatrics · 2016Review
- Pathobiology of Helicobacter pylori-Induced Gastric Cancer.Gastroenterology · 2016Review
- Evaluation of Clinicopathological and Risk Factors for Nonmalignant H. Pylori Associated Gastroduodenal Disorders in Iraqi Patients.Open access Macedonian journal of medical sciences · 2015Article
- Effect of early and current Helicobacter pylori infection on the risk of anaemia in 6.5-year-old Ethiopian children.BMC infectious diseases · 2015Article
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been proposed in the literature, currently there is no consensus. We studied the effects of H. pylori infection on ID/IDA in a cohort of children undergoing upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country.
methodsIn total 311 children (mean age 10.7±3.2 years) from Latin America--Belo Horizonte/Brazil (n = 125), Santiago/Chile (n = 105)--and London/UK (n = 81), were studied. Gastric and duodenal biopsies were obtained for evaluation of histology and H. pylori status and blood samples for parameters of ID/IDA.
resultsThe prevalence of H. pylori infection was 27.7% being significantly higher (p<0.001) in Latin America (35%) than in UK (7%). Multiple linear regression models revealed H. pylori infection as a significant predictor of low ferritin and haemoglobin concentrations in children from Latin-America. A negative correlation was observed between MCV (r = -0.26; p = 0.01) and MCH (r = -0.27; p = 0.01) values and the degree of antral chronic inflammation, and between MCH and the degree of corpus chronic (r = -0.29, p = 0.008) and active (r = -0.27, p = 0.002) inflammation.
conclusionsThis study demonstrates that H. pylori infection in children influences the serum ferritin and haemoglobin concentrations, markers of early depletion of iron stores and anaemia respectively.
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