ArticlePloS one2013
A sexually conditioned switch of chemosensory behavior in C. elegans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
- Single-nucleus neuronal transcriptional profiling of male C. elegans uncovers regulators of sex-specific and sex-shared behaviors.Cell reports · 2025Article
- Male Caenorhabditis elegans optimizes avoidance behavior against acute and chronic stress for successful mating with hermaphrodites.Zoological letters · 2025Article
- Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning.Nature communications · 2025Article
- C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues.Current biology : CB · 2024Article
- Glia in Invertebrate Models: Insights from Caenorhabditis elegans.Advances in neurobiology · 2024Review
- Body stiffness is a mechanical property that facilitates contact-mediated mate recognition in Caenorhabditis elegans.Current biology : CB · 2023Article
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- Sex differences in decision-making: Identifying multisensory behavioral differences in males and hermaphrodites.microPublication biology · 2022Article
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- Article
- Novel Technological Advances in Functional Connectomics inJournal of developmental biology · 2019Review
- PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons ofeLife · 2018Article
- Loss of CaMKI Function Disrupts Salt Aversive Learning inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Sexual Dimorphism and Sex Differences inGenetics · 2018Article
- Building stereotypic connectivity: mechanistic insights into structural plasticity from C. elegans.Current opinion in neurobiology · 2018Review
- A Single Set of Interneurons Drives Opposite Behaviors in C. elegans.Current biology : CB · 2017Article
- Multisensory integration in C. elegans.Current opinion in neurobiology · 2017Review
- Sexual modulation of sex-shared neurons and circuits in Caenorhabditis elegans.Journal of neuroscience research · 2017Review
- Neural circuits for sexually dimorphic and sexually divergent behaviors in Caenorhabditis elegans.Current opinion in neurobiology · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In sexually reproducing animals, mating is essential for transmitting genetic information to the next generation and therefore animals have evolved mechanisms for optimizing the chance of successful mate location. In the soil nematode C. elegans, males approach hermaphrodites via the ascaroside pheromones, recognize hermaphrodites when their tails contact the hermaphrodites' body, and eventually mate with them. These processes are mediated by sensory signals specialized for sexual communication, but other mechanisms may also be used to optimize mate location. Here we describe associative learning whereby males use sodium chloride as a cue for hermaphrodite location. Both males and hermaphrodites normally avoid sodium chloride after associative conditioning with salt and starvation. However, we found that males become attracted to sodium chloride after conditioning with salt and starvation if hermaphrodites are present during conditioning. For this conditioning, which we call sexual conditioning, hermaphrodites are detected by males through pheromonal signaling and additional cue(s). Sex transformation experiments suggest that neuronal sex of males is essential for sexual conditioning. Altogether, these results suggest that C. elegans males integrate environmental, internal and social signals to determine the optimal strategy for mate location.
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Registered trials
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