Evidence map›Paper›PMID 23861854›Full record

ArticlePloS one2013

Reducing the intensity and volume of interval training diminishes cardiovascular adaptation but not mitochondrial biogenesis in overweight/obese men.

J Colin Boyd, Craig A Simpson, Mary E Jung, Brendon J Gurd

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03700671 (The Effects of Low-Volume High Intensity Interval Training and Circuit Training on Maximal Oxygen Uptake), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03700671 nacompletednot on this mapstarted 2016, after this paper: background citation

The Effects of Low-Volume High Intensity Interval Training and Circuit Training on Maximal Oxygen Uptake

TypeinterventionalSponsorUniversity of Central LancashireRan2016 to 2017Enrolled42ConditionsHigh Intensity Interval TrainingArmsHigh intensity interval training, Circuit training
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

  1. Pooled it
  2. Risk of bias and reporting practices in studies comparing VOJournal of sport and health science · 2022
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  5. Sprint exercise snacks: a novel approach to increase aerobic fitness.European journal of applied physiology · 2019
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  14. Heart Rate and Oxygen Uptake During Recovery from High-Intensity Interval Training: A Retrospective Analysis.International journal of environmental research and public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

J Colin BoydSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Craig A Simpson
Mary E Jung
Brendon J Gurd
Queen's University · CAOkanagan University College · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this research was to determine if the adaptations to high intensity interval training (HIT) are mitigated when both intensity and training volume (i.e. exercise energy expenditure) are reduced.

methods19 overweight/obese, sedentary males (Age: 22.7±3.9 yrs, Body Mass Index: 31.4±2.6 kg/m(2), Waist Circumference: 106.5±6.6 cm) performed 9 sessions of interval training using a 1-min on, 1-min off protocol on a cycle ergometer over three weeks at either 70% (LO) or 100% (HI) peak work rate.

resultsCytochrome oxidase I protein content, cytochrome oxidase IV protein content, and citrate synthase maximal activity all demonstrated similar increases between groups with a significant effect of training for each. β-hydroxyacyl-CoA dehydrogenase maximal activity tended to increase with training but did not reach statistical significance (p = 0.07). Peroxisome proliferator-activated receptor gamma coactivator-1α and silent mating type information regulator 2 homolog 1 protein contents also increased significantly (p = 0.047), while AMP-activated protein kinase protein content decreased following the intervention (p = 0.019). VO2peak increased by 11.0±7.4% and 27.7±4.4% in the LO and HI groups respectively with significant effects of both training (p<0.001) and interaction (p = 0.027). Exercise performance improved by 8.6±7.6% in the LO group and 14.1±4.3% in the HI group with a significant effect of training and a significant difference in the improvement between groups. There were no differences in perceived enjoyment or self-efficacy between groups despite significantly lower affect scores during training in the HI group.

conclusionsWhile improvements in aerobic capacity and exercise performance were different between groups, changes in oxidative capacity were similar despite reductions in both training intensity and volume.

Indexed as

Adaptation, PhysiologicalCardiovascular Physiological PhenomenaExerciseAdolescentAdultHumansInflammation MediatorsInsulin ResistanceMaleMitochondrial TurnoverMuscle, SkeletalObesityOverweightOxygen ConsumptionYoung AdultInflammation Mediators

Identifiers

PMID23861854
PMCPMC3702554
OpenAlexW2082344944

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.