ArticlePloS one2013
High levels of DegU-P activate an Esat-6-like secretion system in Bacillus subtilis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- A toxic effector of T7SS facilitates bacterial competition and virulence through membrane damage in Streptococcus suis.Veterinary research · 2026Article
- A novel reverse lipase toxin substrate of themicroLife · 2026Article
- A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system.Science advances · 2025Article
- Differential expression of theApplied and environmental microbiology · 2024Article
- SwrA-mediated Multimerization of DegU and an Upstream Activation Sequence Enhance Flagellar Gene Expression in Bacillus subtilis.Journal of molecular biology · 2024Article
- Article
- Interbacterial competition mediated by the type VIIb secretion system.Microbiology (Reading, England) · 2023Review
- Tuning transcription factor DegU for developing extracellular protease overproducer in Bacillus pumilus.Microbial cell factories · 2023Article
- Plant commensal type VII secretion system causes iron leakage from roots to promote colonization.Nature microbiology · 2023Article
- Article
- The Type VII Secretion System ofAnnual review of microbiology · 2021Article
- Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms.PLoS genetics · 2021Article
- Extreme genetic diversity in the type VII secretion system ofMicrobiology (Reading, England) · 2021Article
- Activation of a bacterial killing machine.PLoS genetics · 2021Article
- Rampant loss of social traits during domestication of a Bacillus subtilis natural isolate.Scientific reports · 2020Article
- A membrane-depolarizing toxin substrate of theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Protein Export into and across the Atypical Diderm Cell Envelope of Mycobacteria.Microbiology spectrum · 2019Review
- Article
- EssC is a specificity determinant for Staphylococcus aureus type VII secretion.Microbiology (Reading, England) · 2018Article
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Authors and funding
3 authors.
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Abstract
The recently discovered Type VII/Esat-6 secretion systems seem to be widespread among bacteria of the phyla Actinobacteria and Firmicutes. In some species they play an important role in pathogenic interactions with eukaryotic hosts. Several studies have predicted that the locus yukEDCByueBC of the non-pathogenic, Gram-positive bacterium Bacillus subtilis would encode an Esat-6-like secretion system (Ess). We provide here for the first time evidences for the functioning of this secretion pathway in an undomesticated B. subtilis strain. We show that YukE, a small protein with the typical features of the secretion substrates from the WXG100 superfamily is actively secreted to culture media. YukE secretion depends on intact yukDCByueBC genes, whose products share sequence or structural homology with known components of the S. aureus Ess. Biochemical characterization of YukE indicates that it exists as a dimer both in vitro and in vivo. We also show that the B. subtilis Ess essentially operates in late stationary growth phase in absolute dependence of phosphorylated DegU, the response regulator of the two-component system DegS-DegU. We present possible reasons that eventually have precluded the study of this secretion system in the B. subtilis laboratory strain 168.
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