ArticlePloS one2013
Patterns of risk of cancer in patients with metal-on-metal hip replacements versus other bearing surface types: a record linkage study between a prospective joint registry and general practice electronic health records in England.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Long-term cancer risk after metal-on-metal hip arthroplasty: a Finnish population-based study with a mean follow-up of 12.8 years.BMJ open · 2026Article
- An update on the effect of metals on stemness properties of mesenchymal stem cells.Journal of materials science. Materials in medicine · 2025Review
- Article
- Possible Transformation of Pseudotumor to Synovial Sarcoma in a Failed Metal-on-Metal Total Hip Arthroplasty.Arthroplasty today · 2024Article
- Article
- No detrimental association between antibiotic use and immune checkpoint inhibitor therapy: an observational cohort study comparing patients with ICI-treated and TKI-treated melanoma and NSCLC.Journal for immunotherapy of cancer · 2024Observational
- Article
- N-Acetyl-Cysteine Reduces Blood Chromium and Cobalt Levels in Metal-on-Metal Hip Arthroplasty.Arthroplasty today · 2020Article
- Mechanisms of Adverse Local Tissue Reactions to Hip Implants.Frontiers in bioengineering and biotechnology · 2019Review
- Midterm risk of cancer with metal-on-metal hip replacements not increased in a Finnish population.Acta orthopaedica · 2018Article
- Article
- The risk of cardiac failure following metal-on-metal hip arthroplasty.The bone & joint journal · 2018Article
- The role of national registries in improving patient safety for hip and knee replacements.BMC musculoskeletal disorders · 2017Article
- Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage.Materials (Basel, Switzerland) · 2016Review
- Article
- How do metal ion levels change over time in hip resurfacing patients? A cohort study.TheScientificWorldJournal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are concerns that metal-on-metal hip implants may cause cancer. The objective of this study was to evaluate patterns and timing of risk of cancer in patients with metal-on-metal total hip replacements (THR).
methodsIn a linkage study between the English National Joint Registry (NJR) and the Clinical Practice Research Datalink (CPRD), we selected all THR surgeries (NJR) between 2003 and 2010 (n = 11,540). THR patients were stratified by type of bearing surface. Patients were followed up for cancer and Poisson regression was used to derive adjusted relative rates (RR).
resultsThe risk of cancer was similar in patients with hip resurfacing (RR 0.69; 95% Confidence Interval [CI] 0.39-1.22) or other types of bearing surfaces (RR 0.96; 95% CI 0.64-1.43) compared to individuals with stemmed metal-on-metal THR. The pattern of cancer risk over time did not support a detrimental effect of metal hip implants. There was substantial confounding: patients with metal-on-metal THRs used fewer drugs and had less comorbidity.
conclusionsMetal-on-metal THRs were not associated with an increased risk of cancer. There were substantial baseline differences between the different hip implants, indicating possibility of confounding in the comparisons between different types of THR implants.
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