ArticlePloS one2013
Live imaging of whole mouse embryos during gastrulation: migration analyses of epiblast and mesodermal cells.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- From Static to Dynamic: Fluorescence Imaging Technology Advances Precise Embryo Evaluation.Small methods · 2026Review
- A method for analysing tissue motion and deformation during mammalian organogenesis.PLoS computational biology · 2025Article
- Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation.eLife · 2025Article
- Trans-scale live-imaging of an E5.5 mouse embryo using incubator-type biaxial light-sheet microscopy.Life science alliance · 2025Article
- Novel application of metabolic imaging of early embryos using a light-sheet on-a-chip device: a proof-of-concept study.Human reproduction (Oxford, England) · 2025Article
- Non-apical mitoses contribute to cell delamination during mouse gastrulation.Nature communications · 2024Article
- The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells.In vitro cellular & developmental biology. Animal · 2024Article
- Automated, High-Throughput Phenotypic Screening and Analysis Platform to Study Pre- and Post-Implantation Morphogenesis in Stem Cell-Derived Embryo-Like Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium.eLife · 2023Article
- Cre recombinase microinjection for single-cell tracing and localised gene targeting.Development (Cambridge, England) · 2023Article
- Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart.Cell · 2023Article
- Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation.Development (Cambridge, England) · 2022Article
- Epiblast fragmentation by shedding-a novel mechanism to eliminate cells in post-implantation mouse embryos.Cell death and differentiation · 2022Article
- ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.Nature communications · 2022Article
- An ex vivo system to study cellular dynamics underlying mouse peri-implantation development.Developmental cell · 2022Article
- Mitosis, a springboard for epithelial-mesenchymal transition?Cell cycle (Georgetown, Tex.) · 2021Article
- Origami: Single-cell 3D shape dynamics oriented along the apico-basal axis of folding epithelia from fluorescence microscopy data.PLoS computational biology · 2021Article
- Advances in live imaging early mouse development: exploring the researcher's interdisciplinary toolkit.Development (Cambridge, England) · 2021Review
- Asymmetry in the frequency and position of mitosis in the mouse embryo epiblast at gastrulation.EMBO reports · 2020Article
- Biophysical research in Okazaki, Japan.Biophysical reviews · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During gastrulation in the mouse embryo, dynamic cell movements including epiblast invagination and mesodermal layer expansion lead to the establishment of the three-layered body plan. The precise details of these movements, however, are sometimes elusive, because of the limitations in live imaging. To overcome this problem, we developed techniques to enable observation of living mouse embryos with digital scanned light sheet microscope (DSLM). The achieved deep and high time-resolution images of GFP-expressing nuclei and following 3D tracking analysis revealed the following findings: (i) Interkinetic nuclear migration (INM) occurs in the epiblast at embryonic day (E)6 and 6.5. (ii) INM-like migration occurs in the E5.5 embryo, when the epiblast is a monolayer and not yet pseudostratified. (iii) Primary driving force for INM at E6.5 is not pressure from neighboring nuclei. (iv) Mesodermal cells migrate not as a sheet but as individual cells without coordination.
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