ArticleEvidence-based complementary and alternative medicine : eCAM2013
A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03907111 (Develop the Biologic-fibrotic Dressing on War Open Bleeding Wounds for Hemostasis.), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Develop the Biologic-fibrotic Dressing on War Open Bleeding Wounds for Hemostasis.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Therapeutic Effects of Medicinal Plants on Cutaneous Wound Healing in Humans: A Systematic Review.Mediators of inflammation · 2018Pooled it
- Dynamic Muscle Stimulation of the Periorbital Area for Improvement of Blinking in Dry Eye Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Trial
- Enhanced wound healing in rat cheeks treated with lavender and ginger oils: A histological study.Journal of Taibah University Medical Sciences · 2026Article
- Using the International Index of Erectile Function-15 in Comparative Analysis Between Transcutaneous Electrical Nerve Stimulation of the Pudendal Nerve and Low-Level Laser Therapy in the Treatment of Erectile Dysfunction After COVID-19.Journal of clinical medicine · 2025Article
- Recovery and Protective Effect of Direct Transcutaneous Electrical Nerve Stimulation in the Treatment of Acute and Subacute Fibular Tunnel Syndrome.Journal of clinical medicine · 2025Article
- Spatial Distribution Dynamics of Sensory Disturbances in the Treatment of Obesity-Related Meralgia Paresthetica Using Transcutaneous Electrical Nerve Stimulation.Journal of clinical medicine · 2025Article
- Multiplicative Effects of Essential Oils and Other Active Components on Skin Tissue and Skin Cancers.International journal of molecular sciences · 2024Review
- Essential Oil ofMolecules (Basel, Switzerland) · 2023Article
- Enhancing Wound Healing: A Novel Topical Emulsion Combining CW49 Peptide and Lavender Essential Oil for Accelerated Regeneration and Antibacterial Protection.Pharmaceutics · 2023Article
- The Effects of Oral Lavender Therapy on Wounding in Chimpanzees (Animals : an open access journal from MDPI · 2023Article
- Current Therapeutic Modalities for the Management of Chronic Diabetic Wounds of the Foot.Journal of diabetes research · 2023Review
- Analgesic effects of high-frequency and low-frequency TENS currents in patients with distal neuropathy.European journal of translational myology · 2022Article
- Growth factor expression is enhanced, and extracellular matrix proteins are depressed in healing skin wounds in septic patients compared with healthy controls.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Article
- Clinical Experience of High Frequency and Low Frequency TENS in Treatment of Diabetic Neuropathic Pain in Russia.Healthcare (Basel, Switzerland) · 2022Article
- Profile of Medicinal Plants Traditionally Used for the Treatment of Skin Burns.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Ferulic Acid-NLC withNanomaterials (Basel, Switzerland) · 2020Article
- Topical application of omega-3-, omega-6-, and omega-9-rich oil emulsions for cutaneous wound healing in rats.Drug delivery and translational research · 2019Article
- Lupeol, a Dietary Triterpene, Enhances Wound Healing in Streptozotocin-Induced Hyperglycemic Rats with Modulatory Effects on Inflammation, Oxidative Stress, and Angiogenesis.Oxidative medicine and cellular longevity · 2019Article
- Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model.BMC complementary and alternative medicine · 2016Article
- Lavandula angustifolia Extract Improves the Result of Human Umbilical Mesenchymal Wharton's Jelly Stem Cell Transplantation after Contusive Spinal Cord Injury in Wistar Rats.Stem cells international · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study compared the effects of transcutaneous electrical nerve stimulation (TENS), saline solution (SS), povidone-iodine (PI), and lavender oil (Lavandula angustifolia) through expression of growth factors in a rat model of wound healing. Six experimental groups were established, each containing 8 rats: a healthy group with no incision wounds, an incision-control group, an incision and TENS group, an incision and SS group, an incision and PI group, and an incision and lavender oil group. Experiments continued for 5 days, after which the skin in the excision area was removed. Tissue concentrations of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF)-A were measured using enzyme-linked immunosorbent assay (ELISA). Tissue expressions of EGF, PDGF-A, and fibroblast growth factor (FGF)-2 were determined using immunohistochemistry. Wound closure progressed more rapidly in the TENS and lavender oil groups than in the control and other study groups. In particular, PDGF-A expressions in the dermis and EGF expression in the epidermis were significantly intense in the TENS group (P < 0.05). In addition, ELISA levels of growth factors such as PDGF-A and EGF were significantly higher in TENS group compared to the control group (P < 0.05). These immunohistochemical and ELISA results suggest that TENS may improve wound healing through increasing growth factors in the dermis and epidermis more than other topical applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.