ArticlePatient preference and adherence2013
Complex sleep apnea syndrome.
Article in Patient preference and adherence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Treatment-emergent central sleep apnea after initiation of hypoglossal nerve stimulator.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- An Atypical Presentation of Central Sleep Apnea in the Context of Bariatric Surgery: A Case Report.Cureus · 2025Article
- Central Sleep Apnea in Adults: An Interdisciplinary Approach to Diagnosis and Management-A Narrative Review.Journal of clinical medicine · 2025Review
- Prevalence of central sleep apnea among veterans and response rate to continuous positive airway pressure therapy.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Investigation of Snoring and Obstructive Sleep Apnea Using Portable Polysomnography in Patients with Temporomandibular Disorder.Dental research and oral health · 2022Article
- The Evaluation of APAP Titration Results: Good Titration Versus TECSA and Unacceptable Titration.Turkish thoracic journal · 2021Article
- Atrial fibrillation is associated with central sleep apnea in clinic patients undergoing diagnostic polysomnography.Journal of arrhythmia · 2020Article
- Central sleep apnea and atrial fibrillation: A review on pathophysiological mechanisms and therapeutic implications.International journal of cardiology. Heart & vasculature · 2020Review
- Predictors of Sleep Apnea in the Canadian Population.Canadian respiratory journal · 2018Article
- The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease.Frontiers in endocrinology · 2018Review
- Positive airway pressure adherence and subthreshold adherence in posttraumatic stress disorder patients with comorbid sleep apnea.Patient preference and adherence · 2017Article
- Clinical predictors of central sleep apnea evoked by positive airway pressure titration.Nature and science of sleep · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex sleep apnea syndrome (CompSAS) is a distinct form of sleep-disordered breathing characterized as central sleep apnea (CSA), and presents in obstructive sleep apnea (OSA) patients during initial treatment with a continuous positive airway pressure (CPAP) device. The mechanisms of why CompSAS occurs are not well understood, though we have a high loop gain theory that may help to explain it. It is still controversial regarding the prevalence and the clinical significance of CompSAS. Patients with CompSAS have clinical features similar to OSA, but they do exhibit breathing patterns like CSA. In most CompSAS cases, CSA events during initial CPAP titration are transient and they may disappear after continued CPAP use for 4~8 weeks or even longer. However, the poor initial experience of CompSAS patients with CPAP may not be avoided, and nonadherence with continued therapy may often result. Treatment options like adaptive servo-ventilation are available now that may rapidly resolve the disorder and relieve the symptoms of this disease with the potential of increasing early adherence to therapy. But these approaches are associated with more expensive and complicated devices. In this review, the definition, potential plausible mechanisms, clinical characteristics, and treatment approaches of CompSAS will be summarized.
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Registered trials
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