ArticleEndocrinology2013
Neural growth hormone implicated in body weight sex differences.
Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- The interplay between X-chromosome functional dosage and circadian regulation in females.Archives of women's mental health · 2024Article
- Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants.European journal of human genetics : EJHG · 2023Article
- Sex Chromosome Complement and Estradiol Modify Cocaine Self-Administration Behaviors in Male Mice.Neuroendocrinology · 2023Article
- Four Core Genotypes and XY* mouse models: Update on impact on SABV research.Neuroscience and biobehavioral reviews · 2020Review
- Sex differences in stroke co-morbidities.Experimental neurology · 2020Review
- Sex chromosome complement influences vulnerability to cocaine in mice.Hormones and behavior · 2020Article
- Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?International journal of molecular sciences · 2019Review
- Sex differences in obesity, lipid metabolism, and inflammation-A role for the sex chromosomes?Molecular metabolism · 2018Review
- Sex differences in obesity: X chromosome dosage as a risk factor for increased food intake, adiposity and co-morbidities.Physiology & behavior · 2017Review
- A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism.Cell metabolism · 2017Review
- Spatiotemporal Regulation of Insulin-Like Growth Factor-1 and Its Receptor in the Brain: Is There a Role for Growth Hormone?Endocrinology · 2017Article
- Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.Scientific reports · 2016Article
- Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus.Endocrine reviews · 2016Review
- The importance of having two X chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues.Biology of sex differences · 2016Review
- Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.Frontiers in neuroendocrinology · 2016Review
- Epigenetics and sex differences in the brain: A genome-wide comparison of histone-3 lysine-4 trimethylation (H3K4me3) in male and female mice.Experimental neurology · 2015Review
- Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice.Biology of sex differences · 2015Article
- Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice.Psychoneuroendocrinology · 2015Article
- Mouse model systems to study sex chromosome genes and behavior: relevance to humans.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
As for many human diseases, the incidence of obesity and its associated health risks are sexually dimorphic: worldwide the rate of obesity is higher in women. Sex differences in metabolism, appetite, body composition, and fat deposition are contributing biological factors. Gonadal hormones regulate the development of many sexually dimorphic traits in humans and animals, and, in addition, studies in mice indicate a role for direct genetic effects of sex chromosome dosage on body weight, deposition of fat, and circadian timing of feeding behavior. Specifically, mice of either sex with 2 X chromosomes, typical of normal females, have heavier body weights, gain more weight, and eat more food during the light portion of the day than mice of either sex with a single X chromosome. Here we test the effects of X chromosome dosage on body weight and report that gonadal females with 2 X chromosomes express higher levels of GH gene (Gh) mRNA in the preoptic area (POA) of the hypothalamus than females with 1 X chromosome and males. Furthermore, Gh expression in the POA of the hypothalamus of mice with 2 X chromosomes correlated with body weight; GH is known to have orexigenic properties. Acute infusion of GH into the POA increased immediate food intake in normal (XY) males. We propose that X inactivation-escaping genes modulate Gh expression and food intake, and this is part of the mechanism by which individuals with 2 X chromosomes are heavier than individuals with a single X chromosome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.