Evidence map›Paper›PMID 23861377›Full record

ArticleEndocrinology2013

Deletion of growth hormone receptors in postnatal skeletal muscle of male mice does not alter muscle mass and response to pathological injury.

Archana Vijayakumar, Nicholas J Buffin, Emily J Gallagher, Jeffrey Blank, Yingjie Wu, Shoshana Yakar, Derek LeRoith

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Growth hormone receptor gene disruption.Vitamins and hormones · 2023
    Article
  2. Review
  3. Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models.International journal of molecular sciences · 2022
    Review
  4. Review
  5. Review
  6. Actions and interactions of IGF-I and MMPs during muscle regeneration.Seminars in cell & developmental biology · 2021
    Review
  7. Article
  8. Myostatin regulates pituitary development and hepatic IGF1.American journal of physiology. Endocrinology and metabolism · 2019
    Article
  9. Insulin/IGF1 signalling mediates the effects of βJournal of cachexia, sarcopenia and muscle · 2019
    Article
  10. Growth Hormone Receptor Mutations Related to Individual Dwarfism.International journal of molecular sciences · 2018
    Review
  11. Article
  12. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016
    Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Archana VijayakumarMD, PhD, Division of Endocrinology, Metabolism, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1055, New York, New York 10029. derek.leroith@mssm.edu.
Nicholas J Buffin
Emily J Gallagher
Jeffrey Blank
Yingjie Wu
Shoshana Yakar
Derek LeRoith
Icahn School of Medicine at Mount Sinai · USNew York University · US

Funding

SERUM IGF-1 DELIVERY SYSTEM AND ITS ROLE IN DETERMINING SKELETAL INTEGRITYR01AR054919 · NIAMS · NEW YORK UNIVERSITY · PI YAKAR, SHOSHANA · 2007 to 2011
$1.8M
THE TEMPORAL AND SPATIAL REGULATION OF BONE ACQUISITION BY SERUM IGF-1R01AR055141 · NIAMS · NEW YORK UNIVERSITY · PI YAKAR, SHOSHANA · 2008 to 2012
$1.8M
NIAMS NIH HHS R01 AR054919NIAMS NIH HHS R01 AR055141
6 · The paper itself

Abstract

In this study, we investigated whether loss of GH receptor (GHR) signaling in postnatal skeletal muscle alters muscle mass and regenerative ability in adult mice and whether this was dependent on IGF-1 receptor (IGF-1R) signaling. To do so, we used mouse models with skeletal muscle-specific loss of GHR signaling (mGHRKO), IGF-1R and insulin receptor signaling (MKR), or both GHR and IGF-1R/insulin receptor signaling (mGHRKO/MKR). We did not find a reduction in muscle cross-sectional area, fiber type composition, or response to pathological muscle injury in male mGHRKO and mGHRKO/MKR mice when compared with control and MKR mice, respectively. This could potentially be explained by unchanged skeletal muscle Igf-1 expression in mGHRKO and mGHRKO/MKR mice relative to control and MKR mice, respectively. Furthermore, MKR and mGHRKO/MKR mice, but not mGHRKO mice, demonstrated reduced fiber fusion after cardiotoxin injection, suggesting that IGF-1, and not GH, promotes fiber fusion in adult mice. In summary, our data suggest that GHR signaling in postnatal skeletal muscle does not play a significant role in regulating muscle mass or muscle regeneration. Additionally, in our model, muscle Igf-1 expression is not dependent on GHR signaling in postnatal skeletal muscle.

Indexed as

Muscle DevelopmentRegenerationSignal TransductionAnimalsCardiotoxinsDiabetes MellitusGrowth HormoneHumansInsulinInsulin-Like Growth Factor IInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicCardiotoxinsGrowth HormoneInsulininsulin-like growth factor-1, mouseInsulin-Like Growth Factor IReceptor, IGF Type 1Receptor, InsulinReceptors, Somatotropin

Identifiers

PMID23861377
PMCPMC5398538
OpenAlexW2136281725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.