ArticleEuropean heart journal2013
Adherence to antihypertensive therapy prior to the first presentation of stroke in hypertensive adults: population-based study.
Article in European heart journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Non-adherence with the treatment regimen and its associated factors among patients with schizophrenia in Sub-Saharan Africa: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women.The Cochrane database of systematic reviews · 2022Pooled it
- BASIS: The blood pressure awareness and insight scale.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- Adherence to Antihypertensive Medications and Stroke Risk: A Dose-Response Meta-Analysis.Journal of the American Heart Association · 2017Pooled it
- Trial
- Cost-effectiveness of Wisconsin TEAM model for improving adherence and hypertension control in black patients.Journal of the American Pharmacists Association : JAPhATrial
- County-Level Contributors to Geographic Variation in Medicare Fee-for-Service Stroke Hospitalization Rates: A Cross-Sectional Study.Journal of the American Heart Association · 2026Article
- Association of healthy lifestyle index and antihypertensive medication use with blood pressure control among employees with hypertension in China based on a workplace-based multicomponent intervention program.Journal of geriatric cardiology : JGC · 2025Article
- Article
- Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension.Journal of the American Heart Association · 2024Article
- Pharmacovigilance monitoring and treatment adherence in patients on antihypertensive drugs at a tertiary care centre.Drugs in context · 2024Article
- Measuring the Influence of Side Effect Expectations, Beliefs, and Incident Side Effects on the Risk for Drug Discontinuation Among Individuals Starting New Medications, a Cross-sectional Study.Patient preference and adherence · 2024Article
- Laboratory testing and antihypertensive medication adherence following initial treatment of incident, uncomplicated hypertension: A real-world data analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Association of adherence measured by self-reported pill count with achieved blood pressure level in hypertension patients: a cross-sectional study.Clinical hypertension · 2022Article
- Pharmacist Interventions for Medication Adherence: Community Guide Economic Reviews for Cardiovascular Disease.American journal of preventive medicine · 2022Review
- Association of Lifestyle Factors and Antihypertensive Medication Use With Risk of All-Cause and Cause-Specific Mortality Among Adults With Hypertension in China.JAMA network open · 2022Article
- Medication Adherence Among Hypertensive Patients Attending Different Primary Health Centers in Abha, Saudi Arabia: A Cross-Sectional Study.Patient preference and adherence · 2022Article
- Medication Adherence and Treatment-Resistant Hypertension in Newly Treated Hypertensive Patients in the United Arab Emirates.Journal of clinical medicine · 2021Article
- Improving patient adherence: the last obstacle to achieving hypertension control.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- A Non-Invasive Method for Detection of Antihypertensive Drugs in Biological Fluids: The Salivary Therapeutic Drug Monitoring.Frontiers in pharmacology · 2021Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
aimsAntihypertensive drug therapy is a major strategy of stroke prevention among hypertensive patients. The aim of this study was to estimate the excess risk of stroke associated with non-adherence to antihypertensive drug therapy among hypertensive patients. METHODS AND
resultsWe conducted a population-based study using records from Finnish national registers for 1 January 1995 to 31 December 2007. Of the 73 527 hypertensive patients aged 30 years or older and without pre-existing stroke or cardiovascular disease, 2144 died from stroke and 24 560 were hospitalized due to stroke during the follow-up. At the 2- and 10-year follow-up after the start of continuous antihypertensive medication, non-adherent patients had 3.81 [95% confidence interval (CI) 2.85-5.10] and 3.01 (95% CI: 2.37-3.83) times higher odds of stroke death when compared with the adherent patients. The corresponding odds ratio (OR) for stroke hospitalization was 2.74 (95% CI: 2.35-3.20) at Year 2 and 1.71 (95% CI: 1.49-1.96) at Year 10. In the stroke-event year, the ORs were higher, 5.68 (95% CI: 5.05-6.39) for stroke death and 1.87 (95% CI: 1.72-2.03) for hospitalization. Among those using agents acting on the renin-angiotensin system combined with diuretics or β-blockers, these ORs were 7.49 (95% CI: 5.62-9.98) and 3.91 (95% CI: 3.23-4.75), respectively. The associations between non-adherence and stroke followed a dose-response pattern--the poorer the adherence, the greater the risk of death and hospitalization due to stroke.
conclusionThese data suggest that poor adherence to antihypertensive therapy substantially increases near- and long-term risk of stroke among hypertensive patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.