ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2013
Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Genomic architecture constrained placental mammal X Chromosome evolution.Genome research · 2021Article
- Conserved role of Ovo in germline development in mouse and Drosophila.Scientific reports · 2017Article
- DNA methylation of the Fthl17 5'-upstream region regulates differential Fthl17 expression in lung cancer cells and germline stem cells.PloS one · 2017Article
- Perturbation of epigenetic processes by doxorubicin in the mouse testis.Toxicology research · 2016Article
- DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.BMC genomics · 2015Article
- Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline.BMC biology · 2015Article
- Functional significance of the sex chromosomes during spermatogenesis.Reproduction (Cambridge, England) · 2015Review
- In quest of genomic treasure.The Journal of reproduction and development · 2015Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
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Abstract
To understand the epigenetic regulation required for germ cell-specific gene expression in the mouse, we analysed DNA methylation profiles of developing germ cells using a microarray-based assay adapted for a small number of cells. The analysis revealed differentially methylated sites between cell types tested. Here, we focused on a group of genomic sequences hypomethylated specifically in germline cells as candidate regions involved in the epigenetic regulation of germline gene expression. These hypomethylated sequences tend to be clustered, forming large (10 kb to ~9 Mb) genomic domains, particularly on the X chromosome of male germ cells. Most of these regions, designated here as large hypomethylated domains (LoDs), correspond to segmentally duplicated regions that contain gene families showing germ cell- or testis-specific expression, including cancer testis antigen genes. We found an inverse correlation between DNA methylation level and expression of genes in these domains. Most LoDs appear to be enriched with H3 lysine 9 dimethylation, usually regarded as a repressive histone modification, although some LoD genes can be expressed in male germ cells. It thus appears that such a unique epigenomic state associated with the LoDs may constitute a basis for the specific expression of genes contained in these genomic domains.
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Registered trials
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