Trial reportDepression and anxiety2014
Patient-reported outcomes of quality of life, functioning, and depressive symptom severity in major depressive disorder comorbid with panic disorder before and after SSRI treatment in the star*d trial.
Trial report in Depression and anxiety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Abstinence and reduced frequency of use are associated with improvements in quality of life among treatment-seekers with cannabis use disorder.The American journal on addictions · 2018Trial
- An examination of symptoms, function and quality of life as conjoint clinical outcome domains for treatment-resistant depression.Journal of mood and anxiety disorders · 2025Article
- Association between mental health status and patient satisfaction: a cross-sectional study in three Damascus hospitals, Syria.BMJ public health · 2025Article
- Comorbid mental disorders, depression symptom severity, and role impairment among Veterans initiating depression treatment through the Veterans Health Administration.Journal of affective disorders · 2021Article
- Clinical Correlates of False Positive Assignment in Bipolar Screening Measures Across Psychiatric Diagnoses among Patients without Bipolar Disorder.Psychiatry investigation · 2020Article
- Patient satisfaction with primary healthcare services: are there any links with patients' symptoms of anxiety and depression?BMC family practice · 2018Article
- Comorbid generalized anxiety disorder and its association with quality of life in patients with major depressive disorder.Scientific reports · 2017Article
- Health-related quality of life among prescription opioid-dependent patients: Results from a multi-site study.The American journal on addictions · 2015Article
- The impacts of migraine and anxiety disorders on painful physical symptoms among patients with major depressive disorder.The journal of headache and pain · 2014Article
- Quality of life as patient-reported outcomes: principles of assessment.Dialogues in clinical neuroscience · 2014Review
- Psychiatric comorbidities in patients with major depressive disorder.Neuropsychiatric disease and treatment · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPanic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity.
methodsUsing data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compared entry and post-SSRI-treatment QOL, functioning, and depressive symptom severity scores in MDD patients with comorbid PD (MDD+PD) to MDD patients without PD (MDDnoPD). We also compared pre- and posttreatment proportions of patients with severe impairments in quality of life and functioning.
resultsMDD+PD patients experienced significantly lower QOL and functioning and more severe depressive symptoms than MDDnoPD patients at entry. Following treatment with citalopram, both groups showed significant improvements, however, nearly 30-60% of patients still suffered from severe quality of life and functioning impairments. MDD+PD patients exited with lower QOL and functioning than MDDnoPD patients, a difference that became statistically insignificant after adjusting for baseline measures of depressive symptom severity, functioning, and QOL, comorbid anxiety disorders (PTSD, GAD, social, and specific phobias), age, and college education.
conclusionsFunctional outcomes using QOL and functioning measures should be utilized in treating and researching MDD so that shortfalls in traditional treatment can be identified and additional interventions can be designed to address severe baseline QOL and functioning deficits in MDD comorbid with PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.