ArticleThe Journal of comparative neurology2014
Birthdating of myenteric neuron subtypes in the small intestine of the mouse.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 88 citations in OpenAlex.
- Time-resolved morphological and transcriptomic characterization of early enteric neuron subtype emergence in chick.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Achaete-Scute-Like 1a Expression Is Essential for the Generation of Correct Proportions of Neuron Subtypes in the Developing Enteric Nervous System of Zebrafish (Gastro hep advances · 2026Article
- Tracing the enteric neural crest cell pathway from origin to colonization: insights into Hirschsprung's disease.Molecular biology reports · 2025Review
- Contribution of neuroligin and neurexin alternative splicing to the establishment of enteric neuronal synaptic specificity.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Intestinal neuron-associated macrophages in health and disease.Nature immunology · 2025Review
- The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine.Nature neuroscience · 2025Article
- Enteric neural stem cell transplant restores gut motility in mice with Hirschsprung disease.JCI insight · 2024Article
- A novel method for culturing enteric neurons generates neurospheres containing functional myenteric neuronal subtypes.Journal of neuroscience methods · 2024Article
- Spatial gene expression profile of Wnt-signaling components in the murine enteric nervous system.Frontiers in immunology · 2024Article
- Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.eLife · 2023Article
- Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system.Development, growth & differentiation · 2023Article
- Article
- hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease.Cell stem cell · 2023Article
- Neonatal development of intestinal neuroimmune interactions.Trends in neurosciences · 2022Review
- Neonatal antibiotics have long term sex-dependent effects on the enteric nervous system.The Journal of physiology · 2022Article
- Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease.NPJ Parkinson's disease · 2022Review
- The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis.Nutrients · 2021Review
- Disorders of the enteric nervous system - a holistic view.Nature reviews. Gastroenterology & hepatology · 2021Review
- An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution.eLife · 2021Article
- scRNA-Seq Reveals New Enteric Nervous System Roles for GDNF, NRTN, and TBX3.Cellular and molecular gastroenterology and hepatology · 2021Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
There are many different types of enteric neurons. Previous studies have identified the time at which some enteric neuron subtypes are born (exit the cell cycle) in the mouse, but the birthdates of some major enteric neuron subtypes are still incompletely characterized or unknown. We combined 5-ethynynl-2'-deoxyuridine (EdU) labeling with antibody markers that identify myenteric neuron subtypes to determine when neuron subtypes are born in the mouse small intestine. We found that different neurochemical classes of enteric neuron differed in their birthdates; serotonin neurons were born first with peak cell cycle exit at E11.5, followed by neurofilament-M neurons, calcitonin gene-related peptide neurons (peak cell cycle exit for both at embryonic day [E]12.5-E13.5), tyrosine hydroxylase neurons (E15.5), nitric oxide synthase 1 (NOS1) neurons (E15.5), and calretinin neurons (postnatal day [P]0). The vast majority of myenteric neurons had exited the cell cycle by P10. We did not observe any EdU+/NOS1+ myenteric neurons in the small intestine of adult mice following EdU injection at E10.5 or E11.5, which was unexpected, as previous studies have shown that NOS1 neurons are present in E11.5 mice. Studies using the proliferation marker Ki67 revealed that very few NOS1 neurons in the E11.5 and E12.5 gut were proliferating. However, Cre-lox-based genetic fate-mapping revealed a small subpopulation of myenteric neurons that appears to express NOS1 only transiently. Together, our results confirm a relationship between enteric neuron subtype and birthdate, and suggest that some enteric neurons exhibit neurochemical phenotypes during development that are different from their mature phenotype.
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