ArticleJournal of biological physics2013
Statistical analysis of sizes and shapes of virus capsids and their resulting elastic properties.
Article in Journal of biological physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Detection and characterization of protein methylation in bacteriophages and their host,mSystems · 2026Article
- A Real-Time Antifouling Multivalent Aptamer Platform for Wash-Free Electrochemical Detection of Low-Abundance Biomarkers in Human Plasma.Angewandte Chemie (International ed. in English) · 2026Article
- Biomechanics Model to Characterize Atomic Force Microscopy-Based Virus-Host Cell Adhesion Measurements.The journal of physical chemistry. B · 2024Article
- Self-Organization of Iron Sulfide Nanoparticles into Complex Multicompartment Supraparticles.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Review
- Size Distribution of Inactivated Tick-Borne Encephalitis Virus Particles Revealed by a Comprehensive Physicochemical Approach.Biomedicines · 2022Article
- Review
- Minimal Design Principles for Icosahedral Virus Capsids.ACS nano · 2021Article
- Scaling relation between genome length and particle size of viruses provides insights into viral life history.iScience · 2021Article
- A comprehensive review on antimicrobial face masks: an emerging weapon in fighting pandemics.RSC advances · 2021Review
- Article
- Electrostatics-Driven Inflation of Elastic Icosahedral Shells as a Model for Swelling of Viruses.Biophysical journal · 2018Article
- Self consistent field theory of virus assembly.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- The effect of RNA stiffness on the self-assembly of virus particles.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Energetic cost of building a virus.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The role of solution conditions in the bacteriophage PP7 capsid charge regulation.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From the analysis of sizes of approximately 130 small icosahedral viruses we find that there is a typical structural capsid protein, having a mean diameter of 5 nm and a mean thickness of 3 nm, with more than two thirds of the analyzed capsid proteins having thicknesses between 2 nm and 4 nm. To investigate whether, in addition to the fairly conserved geometry, capsid proteins show similarities in the way they interact with one another, we examined the shapes of the capsids in detail. We classified them numerically according to their similarity to sphere and icosahedron and an interpolating set of shapes in between, all of them obtained from the theory of elasticity of shells. In order to make a unique and straightforward connection between an idealized, numerically calculated shape of an elastic shell and a capsid, we devised a special shape fitting procedure, the outcome of which is the idealized elastic shape fitting the capsid best. Using such a procedure we performed statistical analysis of a series of virus shapes and we found similarities between the capsid elastic properties of even very different viruses. As we explain in the paper, there are both structural and functional reasons for the convergence of protein sizes and capsid elastic properties. Our work presents a specific quantitative scheme to estimate relatedness between different proteins based on the details of the (quaternary) shape they form (capsid). As such, it may provide an information complementary to the one obtained from the studies of other types of protein similarity, such as the overall composition of structural elements, topology of the folded protein backbone, and sequence similarity.
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