ReviewEuropean journal of applied physiology2014
Blood pressure regulation VIII: resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype.
Review in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Long-Term Systolic Blood Pressure Time in Target Range and Cardiovascular Disease in Individuals With Hypertension.JACC. Advances · 2025Article
- SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice.GeroScience · 2022Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Sympathetic Transduction in Type 2 Diabetes Mellitus.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.Journal of vascular research · 2019Article
- Functional-Optical Coherence Tomography: A Non-invasive Approach to Assess the Sympathetic Nervous System and Intrinsic Vascular Regulation.Frontiers in physiology · 2019Article
- Vasodilator function is impaired in burn injury survivors.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Prolonged leg bending impairs endothelial function in the popliteal artery.Physiological reports · 2017Article
- Prolonged sitting leg vasculopathy: contributing factors and clinical implications.American journal of physiology. Heart and circulatory physiology · 2017Review
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiological reviews · 2017Review
- Caveolae regulate vasoconstriction of conduit arteries to angiotensin II in hindlimb unweighted rats.The Journal of physiology · 2015Article
- Inadequate Blood Pressure Control in Hypertensive Patients Referred for Cardiac Stress Test.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Impact of prolonged sitting on lower and upper limb micro- and macrovascular dilator function.Experimental physiology · 2015Article
- Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.American journal of physiology. Heart and circulatory physiology · 2014Article
- Exploring the vascular smooth muscle receptor landscape in vivo: ultrasound Doppler versus near-infrared spectroscopy assessments.American journal of physiology. Heart and circulatory physiology · 2014Article
- Blood pressure regulation V: in vivo mechanical properties of precapillary vessels as affected by long-term pressure loading and unloading.European journal of applied physiology · 2014Review
- Blood pressure regulation XI: overview and future research directions.European journal of applied physiology · 2014Review
- Differential regulation of adipose tissue and vascular inflammatory gene expression by chronic systemic inhibition of NOS in lean and obese rats.Physiological reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dysfunction of the endothelium is proposed as the primary initiator of atherosclerotic peripheral artery disease, which occurs mainly in medium- to large-sized conduit arteries of the lower extremities (e.g., iliac, femoral, popliteal arteries). In this review article, we propose the novel concept that conduit artery endothelial cell phenotype is determined, in part, by microvascular tone in skeletal muscle resistance arteries through both changes in arterial blood pressure as well as upstream conduit artery shear stress patterns. First, we summarize the literature supporting the involvement of sympathetic nerve activity (SNA) and nitric oxide (NO) in the modulation of microvascular tone and arterial blood pressure. We then focus on the role of elevated blood pressure and shear stress profiles in modulating conduit artery endothelial cell phenotype. Last, we discuss findings from classic and emerging studies indicating that increased vascular resistance, as it occurs in the context of increased SNA and/or reduced NO bioavailability, is associated with greater oscillatory shear stress (e.g., increased retrograde shear) in upstream conduit arteries. The ideas put forth in this review set the stage for a new paradigm concerning the mechanistic link between increased microvascular tone and development of conduit artery endothelial dysfunction and thus increased risk for peripheral artery disease. Indeed, a vast amount of evidence supports the notion that excessive blood pressure and oscillatory shear stress are potent pro-atherogenic signals to the endothelium.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.