ArticleEuropean archives of psychiatry and clinical neuroscience2014
A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cacna1c deficiency in forebrain glutamatergic neurons alters behavior and hippocampal plasticity in female mice.Translational psychiatry · 2024Article
- How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach.Annals of general psychiatry · 2020Review
- Imaging Genetics Towards a Refined Diagnosis of Schizophrenia.Frontiers in psychiatry · 2019Review
- Extinction of Contextual Cocaine Memories Requires CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Genome-Wide Supported Risk Variants inPsychiatry investigation · 2017Article
- Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains.Translational psychiatry · 2017Article
- L-type CaThe Journal of physiology · 2016Review
- CACNA1C risk variant is associated with increased amygdala volume.European archives of psychiatry and clinical neuroscience · 2016Article
- Sex-dependent modulation of age-related cognitive decline by the L-type calcium channel gene Cacna1c (Cav 1.2).The European journal of neuroscience · 2015Article
- [Neurobiology of schizophrenia: new findings from the structure to the molecules].Der Nervenarzt · 2015Review
- Article
- Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease.Trends in neurosciences · 2014Review
- CACNA1C risk variant affects reward responsiveness in healthy individuals.Translational psychiatry · 2014Article
- The new risk variant CACNA1C and brain circuits in schizophrenia.European archives of psychiatry and clinical neuroscience · 2014Article
- The impact of environmental factors in severe psychiatric disorders.Frontiers in neuroscience · 2014Review
- Genetics of bipolar disorder.The application of clinical genetics · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
The alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene is one of the best replicated susceptibility loci for bipolar disorder, schizophrenia and major depression. It is involved in learning, memory and brain plasticity. Genetic studies using functional magnetic resonance imaging (fMRI) reported evidence of association with the CACNA1C single nucleotide polymorphism rs1006737 with functional correlates of episodic memory encoding and retrieval, especially activations in the hippocampus. These results, however, are inconsistent with regard to the magnitude and directionality of effect. In the present study, brain activation was measured with fMRI during an episodic memory encoding and retrieval task using neutral faces in two independent samples of 94 and 111 healthy subjects, respectively. Within whole brain analyses, a main effect of genotype emerged mainly in the right hippocampus during encoding as well as retrieval within the first sample: Carriers of the minor allele (A) exhibited lower activations compared to G/G allele carriers. This effect could be replicated within the second sample, however, only for the retrieval condition. The results strengthen findings that rs1006737 is associated with neural systems related to memory processes in hippocampal regions which are detectable in healthy subjects.
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