ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2013
High-density genotyping: an overkill for QTL mapping? Lessons learned from a case study in maize and simulations.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- High resolution QTL mapping and candidate gene mining for seed oil content and fatty acid composition in soybean.BMC plant biology · 2025Article
- QTL mapping and genome-wide association analysis reveal genetic loci and candidate gene for resistance to gray leaf spot in tropical and subtropical maize germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Modern Breeding Strategies and Tools for Durable Late Blight Resistance in Potato.Plants (Basel, Switzerland) · 2024Review
- Mapping and validation of Fusarium wilt race 2 resistance QTL from Citrullus amarus line USVL246-FR2.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genomic regions associated with chocolate spot (Molecular breeding : new strategies in plant improvement · 2022Article
- Five plants per RIL for phenotyping traits of high or moderate heritability ensure the power of QTL mapping in a rice MAGIC population.Molecular breeding : new strategies in plant improvement · 2022Article
- Fine mapping of candidate quantitative trait loci for plant and ear height in a maize nested-association mapping population.Frontiers in plant science · 2022Article
- Genetic mapping of host resistance to the Pyrenophora teres f. maculata isolate 13IM8.3.G3 (Bethesda, Md.) · 2021Article
- Genetics of Germination and Seedling Traits under Drought Stress in a MAGIC Population of Maize.Plants (Basel, Switzerland) · 2021Article
- Article
- New quantitative trait locus (QTLs) and candidate genes associated with the grape berry color trait identified based on a high-density genetic map.BMC plant biology · 2020Article
- SSR markers developed using next-generation sequencing technology in pineapple,Breeding science · 2020Article
- Seed protein content and its relationships with agronomic traits in pigeonpea is controlled by both main and epistatic effects QTLs.Scientific reports · 2020Article
- QTL Mapping for Agronomic and Adaptive Traits Confirmed Pleiotropic Effect ofFrontiers in genetics · 2020Article
- Developmental Pleiotropy Shaped the Roots of the Domesticated Common Bean (Plant physiology · 2019Article
- Unconditional and conditional QTL analyses of seed fatty acid composition in Brassica napus L.BMC plant biology · 2018Article
- Extracting genotype information of Arabidopsis thaliana recombinant inbred lines from transcript profiles established with high-density oligonucleotide arrays.Plant cell reports · 2017Article
- QTL associated with resistance to cassava brown streak and cassava mosaic diseases in a bi-parental cross of two Tanzanian farmer varieties, Namikonga and Albert.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- QTL mapping and comparative genome analysis of agronomic traits including grain yield in winter rye.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017Article
- Identification of QTLs controlling grain protein concentration using a high-density SNP and SSR linkage map in barley (Hordeum vulgare L.).BMC plant biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-density genotyping is extensively exploited in genome-wide association mapping studies and genomic selection in maize. By contrast, linkage mapping studies were until now mostly based on low-density genetic maps and theoretical results suggested this to be sufficient. This raises the question, if an increase in marker density would be an overkill for linkage mapping in biparental populations, or if important QTL mapping parameters would benefit from it. In this study, we addressed this question using experimental data and a simulation based on linkage maps with marker densities of 1, 2, and 5 cM. QTL mapping was performed for six diverse traits in a biparental population with 204 doubled haploid maize lines and in a simulation study with varying QTL effects and closely linked QTL for different population sizes. Our results showed that high-density maps neither improved the QTL detection power nor the predictive power for the proportion of explained genotypic variance. By contrast, the precision of QTL localization, the precision of effect estimates of detected QTL, especially for small and medium sized QTL, as well as the power to resolve closely linked QTL profited from an increase in marker density from 5 to 1 cM. In conclusion, the higher costs for high-density genotyping are compensated for by more precise estimates of parameters relevant for knowledge-based breeding, thus making an increase in marker density for linkage mapping attractive.
Indexed as
Identifiers
23860723What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.