ArticleJournal of molecular neuroscience : MN2013
FOXO3a involvement in the release of TNF-α stimulated by ATP in spinal cord astrocytes.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells.Purinergic signalling · 2025Article
- Functional Recovery Promotion After Spinal Cord Injury With Astaxanthin Treatment in Preclinical Studies: A Systematic Review and Meta-Analysis.Neurology research international · 2025Review
- FOXO3-induced microRNA-128-3p promotes the progression of spinal cord injury in mice via regulating NLRP3 inflammasome-mediated pyroptosis.Frontiers in immunology · 2025Article
- IL-13 and FOXO3 genes polymorphisms regulate IgE levels in asthmatic patients.Biomedical reports · 2021Article
- Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HTNeuroscience bulletin · 2020Article
- Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats.Experimental and therapeutic medicine · 2019Article
- Tanshinone IIA Attenuates Insulin Like Growth Factor 1 -Induced Cell Proliferation in PC12 Cells through the PI3K/Akt and MEK/ERK Pathways.International journal of molecular sciences · 2018Article
- Lithium Inhibits GSK3β Activity via Two Different Signaling Pathways in Neurons After Spinal Cord Injury.Neurochemical research · 2018Article
- Mechanism of depression as a risk factor in the development of Alzheimer's disease: the function of AQP4 and the glymphatic system.Psychopharmacology · 2017Article
- Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Review
- Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Purinergic signalling · 2016Review
- Lentivirus-mediated inhibition of tumour necrosis factor-α improves motor function associated with PRDX6 in spinal cord contusion rats.Scientific reports · 2015Article
- FOXO3a Gene Polymorphism Associated with Asthma in Indian Population.Molecular biology international · 2015Article
- The regulation of Sox2 and Sox9 stimulated by ATP in spinal cord astrocytes.Journal of molecular neuroscience : MN · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury is characterized by an inflammatory response that includes the increased expression of several cytokines and chemokines. Extracellular adenosine triphosphate (ATP) acts as a critical endogenous signaling molecule in inflammation and immunity. However, the molecular and cellular mechanisms of the proinflammatory cytokines stimulated by ATP are poorly understood. Mammalian forkhead members of the class O (FOXO) are involved in a variety of signaling pathways. In this study, we have found that ATP could selectively decrease the expression of FOXO1 and FOXO3a via the phosphorylation of epidermal growth factor receptor (EGFR) and Akt in spinal cord astrocytes. However, ATP had no effect on the expression of FOXO4 and FOXO6, and EGFR, Akt, and ERK1/2 all involve in the release of interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) induced by ATP. In addition, we have researched that the overexpressed FOXO3a could specially inhibit the release of TNF-α increased by ATP, but the level of IL-6 induced by ATP was not decreased. Meanwhile, there was no change in the release of IL-6 and TNF-α after FOXO1 was overexpressed. Understanding the critical role of FOXO3a in astrocytes stimulated by ATP may provide a potential target for therapeutic intervention after spinal cord injury.
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Registered trials
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