ArticleNeuroepidemiology2013
When do essential tremor patients develop head tremor? Influences of age and duration and evidence of a biological clock.
Article in Neuroepidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 34 citations in OpenAlex.
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- A heterozygous variation of PINK1 is potentially associated with essential tremor in a Chinese family.Neurogenetics · 2025Article
- Cranial Tremors in Essential Tremor: Prevalence, Anatomic Distribution and Predictors of Occurrence.Movement disorders clinical practice · 2025Article
- The Molecular Neuroimaging of Tremor.Current neurology and neuroscience reports · 2021Review
- The Essential Tremors: Evolving Concepts of a Family of Diseases.Frontiers in neurology · 2021Review
- Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol.BMJ open · 2020Article
- Head tremor at disease onset: an ataxic phenotype of cervical dystonia.Journal of neurology · 2019Article
- Defining differences in patient characteristics between spasmodic dysphonia and laryngeal tremor.The Laryngoscope · 2019Article
- The evolving definition of essential tremor: What are we dealing with?Parkinsonism & related disorders · 2018Review
- Dystonia and Tremor: The Clinical Syndromes with Isolated Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2016Review
- Climbing fiber synaptic changes correlate with clinical features in essential tremor.Neurology · 2015Article
- Medication non-adherence in essential tremor.Parkinsonism & related disorders · 2015Article
- Isolated vocal tremor as a focal phenotype of essential tremor: a retrospective case review.Journal of clinical movement disorders · 2015Article
- Familial versus Sporadic Essential Tremor: What Patterns Can One Decipher in Age of Onset?Neuroepidemiology · 2015Article
- Essential tremor: a neurodegenerative disease?Tremor and other hyperkinetic movements (New York, N.Y.) · 2014Article
- Approach to a tremor patient.Annals of Indian Academy of NeurologyArticle
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Abstract
backgroundEssential tremor (ET) is a chronic, progressive neurological disease. Head (neck) tremor may eventually develop in as many as 30-60% of patients, yet it is unclear why. Is its appearance merely a function of advancing disease duration? Alternatively, is patient age a primary factor? The latter would argue for the presence of a biological clock that is important for the expression of this clinical feature of ET.
methodsA total of 363 ET patients were enrolled in a cross-sectional, clinical-epidemiological study. Each ET patient underwent a 20-min videotaped neurological examination which included an assessment of the presence/absence of head tremor.
resultsHead tremor was present on examination in 140 (38.6%) patients. Young patients, even with longer-duration tremor, rarely had head tremor: 2/27 (7.4%) patients<40 years old with tremor duration≥10 years had head tremor versus 121/283 (42.8%) older patients (>60 years old) with tremor duration≥10 years (p<0.001). In a multivariate logistic regression analysis, while head tremor was associated with age (p<0.001) it was not independently associated with tremor duration (p=0.26); interestingly, it was associated with gender in that model (p<0.001). With the exception of 1 patient, head tremor did not begin before the age of 36.
conclusionsData suggest that the appearance of head tremor in ET depends on a biological factor that is intrinsic to the patient (i.e. age) and is not a clear consequence of advancing disease duration.
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