ArticleMedical science monitor : international medical journal of experimental and clinical research2013
Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinoma.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Low Prevalence of HSV-1 andDiagnostics (Basel, Switzerland) · 2023Article
- Effects ofWorld journal of gastrointestinal oncology · 2022Review
- Is Laryngeal Squamous Cell Carcinoma Related toFrontiers in oncology · 2022Article
- Review
- Genome ofInternational journal of environmental research and public health · 2021Article
- LaryngealMicroorganisms · 2021Article
- [Analysis of the association between helicobacter pylori infection and laryngeal lesions].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Article
- Presence of Helicobacter Pylori in the Stomach and Laryngeal Mucosal Linings in Patients with Laryngeal Cancer.Acta clinica Croatica · 2018Article
- Host pathogen interactions inWorld journal of gastroenterology · 2017Review
- ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer.Oncotarget · 2016Article
- UreA and cagA genes of Helicobacter pylori in Egyptian patients with laryngeal squamous cell carcinoma and benign laryngeal polyps: a cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Observational
- The presence of Helicobacter pylori in laryngeal squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Association between CYP1B1 gene polymorphisms and risk factors and susceptibility to laryngeal cancer.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment.World journal of gastroenterology · 2014Review
- Helicobacter pylori infection: new pathogenetic and clinical aspects.World journal of gastroenterology · 2014Review
- Two Cases of Thyroid Metastasis from Head and Neck Squamous Cell Carcinoma Detected by FDG-PET/CT.Journal of clinical imaging science · 2014Article
- Clinical experiences of NBI laryngoscope in diagnosis of laryngeal lesions.International journal of clinical and experimental medicine · 2014Article
- Characterization and comparison of bacterial communities in benign vocal fold lesions.Microbiome · 2014Article
- Upregulated TIMP-1 correlates with poor prognosis of laryngeal squamous cell carcinoma.International journal of clinical and experimental pathology · 2014Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the study was to evaluate the presence of cagA gene Helicobacter pylori in etiopathogenesis of initiation and development of larynx squamous cell carcinoma (LSCC) and its predictable role as a prognostic factor. MATERIAL AND
methodsThe prospective, controlled study involved a series of 75 patients (65 male, 10 female, mean age 59.1 years, range 43 to 79 years) with larynx cancer. Samples of larynx cancerous tissue, each of 10-15 mg, were obtained from fresh tissues and were used for nucleic acid purification. DNA was extracted from 225 samples (larynx tumor - I (75), margin of tumor and normal tissue - II (75) and normal larynx tissue from opposite side to the tumor - III). All samples were subjected to H. pylori ureA detection by the PCR H. pylori diagnostic test. Samples that were positive for ureA H. pylori gene were evaluated for cagA H. pylori gene.
resultsPresence of H. pylori cagA gene was identified in 46,7% to 49,3% of 75 H. pylori ureA gene-positive larynx cancer depending of tissue location. There was a correlation of high incidence of positive cagA gene in larynx cancer tissue in supraglottic versus subglottic and glottic location. We observed a predominance of cagA gene in LSCC in patients with positive cervical lymph nodes and clinical stage T3 and T4.
conclusionsH. pylori is present in larynx tissue and may be a possible carcinogen or co-carcinogen in LSCC development, but that must be addressed by future investigations. The presence of cagA gene in larynx cancer tissues significantly decreases survival rate and increases the disease recurrence possibilities.
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